Encephalopathy (HP:0001298)
Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.
Synonyms: No synonyms found for this term.
Comment: This term and its children are general and bundled terms that are kept for convenience. For new annotations, it is recommended that the specific phenotypic abnormalities be noted.
Cross References: MSH:D001927, SNOMEDCT_US:81308009, UMLS:C0085584
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 6.174e-12 | 1.667e-10 | 570.14 | 14715.76 |
| 2 | GABAergic synapse | 7.537e-8 | 0.000001017 | 156.12 | 2560.47 |
| 3 | Morphine addiction | 0.00001068 | 0.00007212 | 96.93 | 1109.48 |
| 4 | Cocaine addiction | 0.0002613 | 0.001008 | 106.08 | 875.14 |
| 5 | Neuroactive ligand-receptor interaction | 3.287e-7 | 0.000002958 | 58.49 | 873.21 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic transmission, GABAergic (GO:0051932) | 1.482e-8 | 2.964e-7 | 1070.46 | 19297.66 |
| 2 | inhibitory synapse assembly (GO:1904862) | 1.482e-8 | 2.964e-7 | 1070.46 | 19297.66 |
| 3 | cellular response to histamine (GO:0071420) | 0.000004719 | 0.00004356 | 999.25 | 12254.80 |
| 4 | excitatory chemical synaptic transmission (GO:0098976) | 0.000004719 | 0.00004356 | 999.25 | 12254.80 |
| 5 | regulation of postsynaptic membrane potential (GO:0060078) | 1.637e-9 | 6.549e-8 | 429.23 | 8683.34 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glutamate-gated calcium ion channel activity (GO:0022849) | 0.000002248 | 0.00001799 | 1665.58 | 21661.60 |
| 2 | GABA-gated chloride ion channel activity (GO:0022851) | 2.567e-8 | 0.000001232 | 856.29 | 14966.03 |
| 3 | NMDA glutamate receptor activity (GO:0004972) | 0.000006290 | 0.00003355 | 832.67 | 9972.50 |
| 4 | ligand-gated anion channel activity (GO:0099095) | 7.315e-8 | 0.000001390 | 570.71 | 9377.24 |
| 5 | GABA-A receptor activity (GO:0004890) | 8.685e-8 | 0.000001390 | 535.02 | 8698.92 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | integral component of plasma membrane (GO:0005887) | 4.006e-12 | 1.082e-10 | 185460.00 | 4867070.13 |
| 2 | NMDA selective glutamate receptor complex (GO:0017146) | 0.000006290 | 0.00002830 | 832.67 | 9972.50 |
| 3 | GABA-A receptor complex (GO:1902711) | 8.685e-8 | 7.816e-7 | 535.02 | 8698.92 |
| 4 | neuron projection (GO:0043005) | 1.454e-11 | 1.963e-10 | 141.91 | 3541.27 |
| 5 | voltage-gated sodium channel complex (GO:0001518) | 0.00003048 | 0.0001176 | 332.92 | 3461.84 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| GABRG2 | – |
| SCN2A | – |
| SLC6A1 | TIAGABINE, TIAGABINE HYDROCHLORIDE |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| SCN1A | ETHOSUXIMIDE |
| GRIN2B | MEMANTINE, FELBAMATE, ACAMPROSATE |
| KCNA2 | – |
| NRXN1 | DULOXETINE |
| GABRB2 | – |
