Confusion (HP:0001289)
Lack of clarity and coherence of thought, perception, understanding, or action.
Synonyms: Confusion, Disorientation, Easily confused, Mental disorientation
Cross References: MSH:D003221, SNOMEDCT_US:286933003, UMLS:C0009676
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nucleotide excision repair | 0.000001443 | 0.00001443 | 194.28 | 2612.86 |
| 2 | Arginine biosynthesis | 0.01095 | 0.03979 | 105.66 | 476.99 |
| 3 | Vitamin digestion and absorption | 0.01194 | 0.03979 | 96.46 | 427.12 |
| 4 | Basal transcription factors | 0.02228 | 0.05336 | 50.37 | 191.61 |
| 5 | Fanconi anemia pathway | 0.02668 | 0.05336 | 41.80 | 151.46 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | nucleotide-excision repair, DNA incision, 3′-to lesion (GO:0006295) | 1.191e-7 | 0.000009233 | 475.52 | 7581.26 |
| 2 | nucleotide-excision repair, preincision complex stabilization (GO:0006293) | 1.191e-7 | 0.000009233 | 475.52 | 7581.26 |
| 3 | negative regulation of telomerase activity (GO:0051974) | 0.00001010 | 0.0002610 | 624.44 | 7182.69 |
| 4 | urea cycle (GO:0000050) | 0.00001010 | 0.0002610 | 624.44 | 7182.69 |
| 5 | UV protection (GO:0009650) | 0.00001010 | 0.0002610 | 624.44 | 7182.69 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | deoxyribonuclease activity (GO:0004536) | 0.00002041 | 0.0005613 | 416.21 | 4494.85 |
| 2 | oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor (GO:0016723) | 0.002498 | 0.01249 | 555.17 | 3326.77 |
| 3 | L-ornithine transmembrane transporter activity (GO:0000064) | 0.002498 | 0.01249 | 555.17 | 3326.77 |
| 4 | Y-form DNA binding (GO:0000403) | 0.002498 | 0.01249 | 555.17 | 3326.77 |
| 5 | apolipoprotein A-I binding (GO:0034186) | 0.002498 | 0.01249 | 555.17 | 3326.77 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transcription factor TFIIH core complex (GO:0000439) | 0.004990 | 0.04870 | 246.68 | 1307.49 |
| 2 | transcription factor TFIIH holo complex (GO:0005675) | 0.005985 | 0.04870 | 201.81 | 1032.95 |
| 3 | acetylcholine-gated channel complex (GO:0005892) | 0.006979 | 0.04870 | 170.74 | 847.70 |
| 4 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.04870 | 138.71 | 661.82 |
| 5 | sodium channel complex (GO:0034706) | 0.01243 | 0.05706 | 92.44 | 405.55 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ERCC4 | – |
| ERCC2 | OXALIPLATIN, LEUCOVORIN |
| NAGS | – |
| SCN1A | ETHOSUXIMIDE |
| SLC25A15 | – |
| ERCC5 | – |
| MEN1 | OLSALAZINE |
| MMACHC | – |
| CHRNA2 | PIPECURONIUM, METOCURINE, CISATRACURIUM, PANCURONIUM, MECAMYLAMINE, DOXACURIUM, MIVACURIUM, DECAMETHONIUM, VECURONIUM, TUBOCURARINE |
| TREM2 | – |
