Abnormality of higher mental function (HP:0011446)
Cognitive, psychiatric or memory anomaly.
Synonyms: No synonyms found for this term.
Cross References: UMLS:C4023352
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Phototransduction | 0.00008446 | 0.0005068 | 191.96 | 1800.45 |
| 2 | Retinol metabolism | 0.03349 | 0.09401 | 33.04 | 112.22 |
| 3 | Drug metabolism | 0.05272 | 0.09401 | 20.65 | 60.76 |
| 4 | Purine metabolism | 0.06267 | 0.09401 | 17.24 | 47.76 |
| 5 | cGMP-PKG signaling pathway | 0.08045 | 0.09654 | 13.27 | 33.44 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | protein localization to ciliary transition zone (GO:1904491) | 0.002997 | 0.02240 | 444.11 | 2580.41 |
| 2 | protein localization to non-motile cilium (GO:0097499) | 0.002997 | 0.02240 | 444.11 | 2580.41 |
| 3 | visual perception (GO:0007601) | 9.004e-8 | 0.000002895 | 149.07 | 2418.38 |
| 4 | sensory perception of light stimulus (GO:0050953) | 9.813e-8 | 0.000002895 | 145.78 | 2352.45 |
| 5 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 0.00006709 | 0.001319 | 217.03 | 2085.58 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | guanylate cyclase activator activity (GO:0030250) | 0.002498 | 0.01921 | 555.17 | 3326.77 |
| 2 | NADP-retinol dehydrogenase activity (GO:0052650) | 0.002997 | 0.01921 | 444.11 | 2580.41 |
| 3 | intracellular cGMP-activated cation channel activity (GO:0005223) | 0.003495 | 0.01921 | 370.07 | 2093.27 |
| 4 | intracellular cAMP-activated cation channel activity (GO:0005222) | 0.004492 | 0.01921 | 277.53 | 1500.17 |
| 5 | leucine zipper domain binding (GO:0043522) | 0.004990 | 0.01921 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | sperm flagellum (GO:0036126) | 0.02570 | 0.1766 | 43.44 | 159.04 |
| 2 | 9+2 motile cilium (GO:0097729) | 0.02814 | 0.1766 | 39.55 | 141.22 |
| 3 | azurophil granule lumen (GO:0035578) | 0.04411 | 0.1766 | 24.85 | 77.54 |
| 4 | cytoplasmic vesicle lumen (GO:0060205) | 0.05605 | 0.1766 | 19.37 | 55.82 |
| 5 | ficolin-1-rich granule lumen (GO:1904813) | 0.05984 | 0.1766 | 18.09 | 50.96 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RPGR | – |
| IMPDH1 | MYCOPHENOLATE MOFETIL HYDROCHLORIDE, RIBAVIRIN, MYCOPHENOLATE MOFETIL, MYCOPHENOLIC ACID |
| RDH12 | – |
| CRX | – |
| SPATA7 | – |
| PRPH2 | – |
| TULP1 | – |
| CNGA1 | DEQUALINIUM |
| NR2E3 | – |
| GUCA1B | – |
