Short attention span (HP:0000736)
Reduced attention span characterized by distractibility and impulsivity but not necessarily satisfying the diagnostic criteria for attention deficit hyperactivity disorder.
Synonyms: Easily distracted, Poor attention span, Problem paying attention, Short attention span
Cross References: SNOMEDCT_US:247762003, UMLS:C0262630
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 8.806e-7 | 0.00002114 | 231.12 | 3222.36 |
| 2 | GABAergic synapse | 0.000009993 | 0.0001199 | 99.19 | 1142.03 |
| 3 | Taste transduction | 0.0008042 | 0.004319 | 59.24 | 422.16 |
| 4 | Morphine addiction | 0.0008998 | 0.004319 | 55.90 | 392.06 |
| 5 | Dopaminergic synapse | 0.001879 | 0.007516 | 38.19 | 239.73 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuronal action potential (GO:0019228) | 2.294e-10 | 1.698e-8 | 739.70 | 16417.99 |
| 2 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.00005710 | 555.03 | 6273.06 |
| 3 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.00005710 | 555.03 | 6273.06 |
| 4 | action potential (GO:0001508) | 4.648e-9 | 1.720e-7 | 324.37 | 6223.71 |
| 5 | membrane depolarization during action potential (GO:0086010) | 2.326e-7 | 0.000002869 | 372.06 | 5682.76 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.0001296 | 624.44 | 7182.69 |
| 2 | voltage-gated sodium channel activity (GO:0005248) | 1.379e-7 | 0.000005792 | 450.47 | 7115.97 |
| 3 | extracellular ligand-gated ion channel activity (GO:0005230) | 0.00001235 | 0.0001296 | 555.03 | 6273.06 |
| 4 | GABA-gated chloride ion channel activity (GO:0022851) | 0.00001750 | 0.0001429 | 454.07 | 4973.59 |
| 5 | inhibitory extracellular ligand-gated ion channel activity (GO:0005237) | 0.00002041 | 0.0001429 | 416.21 | 4494.85 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.098e-8 | 2.896e-7 | 611.51 | 10158.88 |
| 2 | sodium channel complex (GO:0034706) | 2.058e-7 | 7.821e-7 | 388.99 | 5988.96 |
| 3 | GABA-A receptor complex (GO:1902711) | 0.00003830 | 0.0001213 | 293.72 | 2987.15 |
| 4 | integral component of plasma membrane (GO:0005887) | 5.182e-10 | 9.846e-9 | 115.51 | 2469.57 |
| 5 | NMDA selective glutamate receptor complex (GO:0017146) | 0.003994 | 0.007588 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN1A | ETHOSUXIMIDE |
| SCN2A | – |
| GABRG2 | – |
| KCNT1 | CLOFILIUM, LOXAPINE, QUINIDINE |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| SCN8A | – |
| KCNA2 | – |
| PCDH19 | – |
| SLC6A1 | TIAGABINE, TIAGABINE HYDROCHLORIDE |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
