Polydipsia (HP:0001959)
Excessive thirst manifested by excessive fluid intake.
Synonyms: Extreme thirst
Cross References: MSH:D059606, SNOMEDCT_US:17173007, SNOMEDCT_US:267026004, UMLS:C0085602
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone signaling pathway | 0.000007427 | 0.0003417 | 126.32 | 1491.93 |
| 2 | Notch signaling pathway | 0.0001780 | 0.002373 | 139.90 | 1207.91 |
| 3 | Long-term potentiation | 0.0002297 | 0.002373 | 122.63 | 1027.54 |
| 4 | Renal cell carcinoma | 0.0002436 | 0.002373 | 118.96 | 989.76 |
| 5 | Adherens junction | 0.0002579 | 0.002373 | 115.50 | 954.36 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | peptidyl-lysine acetylation (GO:0018394) | 0.000004719 | 0.0004823 | 999.25 | 12254.80 |
| 2 | N-terminal protein amino acid acetylation (GO:0006474) | 0.00001257 | 0.0004823 | 570.83 | 6441.32 |
| 3 | positive regulation of transcription of Notch receptor target (GO:0007221) | 0.00001424 | 0.0004823 | 532.75 | 5945.01 |
| 4 | negative regulation of cellular respiration (GO:1901856) | 0.001749 | 0.008819 | 832.88 | 5287.72 |
| 5 | foam cell differentiation (GO:0090077) | 0.002098 | 0.009751 | 666.27 | 4108.59 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468) | 0.001749 | 0.008538 | 832.88 | 5287.72 |
| 2 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.001749 | 0.008538 | 832.88 | 5287.72 |
| 3 | STAT family protein binding (GO:0097677) | 0.002098 | 0.008538 | 666.27 | 4108.59 |
| 4 | superoxide-generating NADPH oxidase activator activity (GO:0016176) | 0.002797 | 0.01002 | 475.86 | 2797.66 |
| 5 | histone acetyltransferase activity (GO:0004402) | 0.00004859 | 0.001114 | 275.37 | 2734.96 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phagolysosome (GO:0032010) | 0.001749 | 0.01137 | 832.88 | 5287.72 |
| 2 | elastic fiber (GO:0071953) | 0.001749 | 0.01137 | 832.88 | 5287.72 |
| 3 | NADPH oxidase complex (GO:0043020) | 0.004193 | 0.01724 | 302.76 | 1657.40 |
| 4 | secondary lysosome (GO:0005767) | 0.005587 | 0.01724 | 221.98 | 1151.45 |
| 5 | supramolecular fiber (GO:0099512) | 0.006632 | 0.01724 | 184.95 | 927.70 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| EP300 | – |
| CREBBP | – |
| ESR1 | CLOMIPHENE, LEVONORGESTREL |
| MLXIPL | – |
| ELN | – |
| NCF1 | – |
| DNAJC30 | – |
