Obsessive compulsive disorder (HP:0000722)
Recurrent obsessions or compulsions that are severe enough to be time consuming (i.e., they take more than 1 hour a day) or cause marked distress or significant impairment (DSM-IV).
Synonyms: Obsessive compulsive behavior, Obsessive-compulsive behavior, Obsessive compulsive behaviour, Obsessive-compulsive behaviour, OCD, Obsessive compulsive disorder, Obsessive-compulsive disorder
Cross References: MSH:D003192, MSH:D009771, SNOMEDCT_US:12479006, SNOMEDCT_US:191736004, UMLS:C0028768, UMLS:C0600104
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 2.854e-9 | 1.199e-7 | 369.52 | 7270.07 |
| 2 | Retrograde endocannabinoid signaling | 5.840e-7 | 0.00001226 | 91.88 | 1318.78 |
| 3 | Taste transduction | 0.000009013 | 0.00008975 | 102.79 | 1194.10 |
| 4 | GABAergic synapse | 0.000009993 | 0.00008975 | 99.19 | 1142.03 |
| 5 | Morphine addiction | 0.00001068 | 0.00008975 | 96.93 | 1109.48 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization during action potential (GO:0086010) | 4.685e-10 | 7.683e-8 | 605.09 | 12998.28 |
| 2 | membrane depolarization (GO:0051899) | 1.125e-9 | 9.227e-8 | 475.29 | 9793.38 |
| 3 | neuronal action potential (GO:0019228) | 1.379e-7 | 0.000004524 | 450.47 | 7115.97 |
| 4 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.0001446 | 555.03 | 6273.06 |
| 5 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.0001446 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 2.294e-10 | 9.637e-9 | 739.70 | 16417.99 |
| 2 | GABA-A receptor activity (GO:0004890) | 8.685e-8 | 0.000001216 | 535.02 | 8698.92 |
| 3 | sodium channel activity (GO:0005272) | 2.307e-9 | 4.844e-8 | 391.29 | 7781.87 |
| 4 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.00005304 | 624.44 | 7182.69 |
| 5 | GABA receptor activity (GO:0016917) | 1.379e-7 | 0.000001448 | 450.47 | 7115.97 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 7.474e-11 | 1.719e-9 | 1024.46 | 23887.38 |
| 2 | sodium channel complex (GO:0034706) | 3.965e-10 | 3.973e-9 | 633.94 | 13723.68 |
| 3 | GABA-A receptor complex (GO:1902711) | 8.685e-8 | 3.995e-7 | 535.02 | 8698.92 |
| 4 | integral component of plasma membrane (GO:0005887) | 5.182e-10 | 3.973e-9 | 115.51 | 2469.57 |
| 5 | neuron to neuron synapse (GO:0098984) | 0.003994 | 0.009185 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GABRG2 | – |
| SCN1A | ETHOSUXIMIDE |
| SCN2A | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| GABRD | – |
| SCN1B | ZONISAMIDE |
| GRIA2 | PERAMPANEL |
| SCN9A | – |
| PCDH19 | – |
| EP300 | – |
