Vomiting (HP:0002013)
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
Synonyms: Throwing up, Vomiting, Emesis
Cross References: MEDDRA:10047700, MSH:D014839, SNOMEDCT_US:249497008, SNOMEDCT_US:300359004, SNOMEDCT_US:422400008, UMLS:C0042963
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Oxidative phosphorylation | 1.586e-11 | 3.250e-10 | 234.60 | 5833.97 |
| 2 | Thermogenesis | 3.007e-12 | 1.233e-10 | 204.97 | 5437.89 |
| 3 | Retrograde endocannabinoid signaling | 3.038e-11 | 4.124e-10 | 209.66 | 5077.41 |
| 4 | Non-alcoholic fatty liver disease | 4.023e-11 | 4.124e-10 | 199.74 | 4781.09 |
| 5 | Diabetic cardiomyopathy | 2.061e-10 | 1.408e-9 | 150.71 | 3361.18 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 1.353e-19 | 1.583e-17 | 1595.20 | 69306.12 |
| 2 | NADH dehydrogenase complex assembly (GO:0010257) | 1.353e-19 | 1.583e-17 | 1595.20 | 69306.12 |
| 3 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.457e-18 | 4.257e-16 | 971.12 | 38601.66 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 7.666e-15 | 4.485e-13 | 907.14 | 29483.69 |
| 5 | aerobic electron transport chain (GO:0019646) | 3.065e-13 | 1.305e-11 | 467.02 | 13456.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NADH dehydrogenase (quinone) activity (GO:0050136) | 3.049e-12 | 3.507e-11 | 665.33 | 17642.09 |
| 2 | NADH dehydrogenase (ubiquinone) activity (GO:0008137) | 3.049e-12 | 3.507e-11 | 665.33 | 17642.09 |
| 3 | oxidoreduction-driven active transmembrane transporter activity (GO:0015453) | 4.283e-11 | 3.284e-10 | 376.17 | 8980.56 |
| 4 | morphogen activity (GO:0016015) | 0.003495 | 0.01340 | 370.07 | 2093.27 |
| 5 | NADH dehydrogenase activity (GO:0003954) | 0.003495 | 0.01340 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial respiratory chain complex I (GO:0005747) | 1.232e-14 | 1.355e-13 | 831.42 | 26628.24 |
| 2 | respiratory chain complex I (GO:0045271) | 1.232e-14 | 1.355e-13 | 831.42 | 26628.24 |
| 3 | mitochondrial inner membrane (GO:0005743) | 3.444e-11 | 2.525e-10 | 142.97 | 3444.50 |
| 4 | mitochondrial envelope (GO:0005740) | 2.343e-9 | 8.590e-9 | 162.85 | 3236.19 |
| 5 | organelle inner membrane (GO:0019866) | 5.010e-11 | 2.756e-10 | 135.26 | 3207.90 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NDUFS3 | – |
| NDUFAF4 | – |
| NDUFA1 | – |
| NDUFA6 | – |
| NDUFB10 | – |
| NDUFB11 | – |
| NDUFS1 | – |
| TIMMDC1 | – |
| CTNNB1 | FLUORESCEN SODIUM |
| SHH | VISMODEGIB, CAFFEINE |
