Poor appetite (HP:0004396)
A reduced desire to eat.
Synonyms: Decreased appetite, Poor appetite, No appetite, Loss of appetite
Cross References: SNOMEDCT_US:64379006, UMLS:C0232462
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid cancer | 0.0001485 | 0.005965 | 142.54 | 1256.48 |
| 2 | Homologous recombination | 0.0001826 | 0.005965 | 127.89 | 1100.92 |
| 3 | Fanconi anemia pathway | 0.0003175 | 0.007780 | 95.86 | 772.11 |
| 4 | Apelin signaling pathway | 0.00003643 | 0.003570 | 63.51 | 649.04 |
| 5 | Chronic myeloid leukemia | 0.0006287 | 0.009585 | 67.28 | 496.00 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.000002248 | 0.0001776 | 1665.58 | 21661.60 |
| 2 | regulation of histone H3-K9 acetylation (GO:2000615) | 0.00001235 | 0.0007315 | 555.03 | 6273.06 |
| 3 | positive regulation of histone H3-K4 methylation (GO:0051571) | 0.00002354 | 0.001116 | 384.17 | 4094.01 |
| 4 | actin-myosin filament sliding (GO:0033275) | 7.523e-7 | 0.00008915 | 244.35 | 3445.31 |
| 5 | muscle filament sliding (GO:0030049) | 7.523e-7 | 0.00008915 | 244.35 | 3445.31 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin heavy chain binding (GO:0032036) | 0.003495 | 0.03337 | 370.07 | 2093.27 |
| 2 | arginine binding (GO:0034618) | 0.003994 | 0.03337 | 317.19 | 1751.86 |
| 3 | L-aspartate transmembrane transporter activity (GO:0015183) | 0.004492 | 0.03337 | 277.53 | 1500.17 |
| 4 | I-SMAD binding (GO:0070411) | 0.006482 | 0.03337 | 184.98 | 932.06 |
| 5 | L-glutamate transmembrane transporter activity (GO:0005313) | 0.006979 | 0.03337 | 170.74 | 847.70 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 0.002498 | 0.01399 | 555.17 | 3326.77 |
| 2 | actin filament (GO:0005884) | 0.000005272 | 0.0001476 | 123.73 | 1503.75 |
| 3 | actin cytoskeleton (GO:0015629) | 0.00001191 | 0.0001668 | 42.05 | 476.73 |
| 4 | excitatory synapse (GO:0060076) | 0.01243 | 0.04786 | 92.44 | 405.55 |
| 5 | myofibril (GO:0030016) | 0.01342 | 0.04786 | 85.32 | 367.79 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PALB2 | OLAPARIB, MITOMYCIN |
| BRCA1 | – |
| SMAD4 | LYSINE, ALECTINIB |
| KRAS | PANITUMUMAB, CETUXIMAB |
| ACTA1 | – |
| PALLD | – |
| TPM3 | CORTICOTROPIN |
| MYL2 | – |
| NAGS | – |
| SLC25A13 | – |
