Nausea (HP:0002018)
A sensation of unease in the stomach together with an urge to vomit.
Synonyms: Nausea
Pubmed References: PMID:26770271
Cross References: MEDDRA:10028813, MSH:D009325, SNOMEDCT_US:422587007, UMLS:C0027497
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Central carbon metabolism in cancer | 0.0005336 | 0.007471 | 73.24 | 551.94 |
| 2 | Citrate cycle (TCA cycle) | 0.01490 | 0.07824 | 76.48 | 321.69 |
| 3 | Thyroid cancer | 0.01835 | 0.08564 | 61.59 | 246.23 |
| 4 | MAPK signaling pathway | 0.0003495 | 0.007340 | 29.01 | 230.90 |
| 5 | Pathways in cancer | 0.00009084 | 0.003815 | 24.62 | 229.14 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of phospholipase C activity (GO:1900274) | 0.00002354 | 0.003932 | 384.17 | 4094.01 |
| 2 | glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860) | 0.002498 | 0.02831 | 555.17 | 3326.77 |
| 3 | atrial cardiac muscle cell membrane repolarization (GO:0099624) | 0.002498 | 0.02831 | 555.17 | 3326.77 |
| 4 | positive regulation of smooth muscle cell differentiation (GO:0051152) | 0.002498 | 0.02831 | 555.17 | 3326.77 |
| 5 | membrane repolarization during atrial cardiac muscle cell action potential (GO:0098914) | 0.002498 | 0.02831 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.002498 | 0.02498 | 555.17 | 3326.77 |
| 2 | Y-form DNA binding (GO:0000403) | 0.002498 | 0.02498 | 555.17 | 3326.77 |
| 3 | phosphatidylethanolamine binding (GO:0008429) | 0.004492 | 0.02807 | 277.53 | 1500.17 |
| 4 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) | 0.005985 | 0.03325 | 201.81 | 1032.95 |
| 5 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) | 0.007476 | 0.03738 | 158.54 | 776.21 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | MLL1 complex (GO:0071339) | 0.01293 | 0.06103 | 88.73 | 385.85 |
| 2 | MLL1/2 complex (GO:0044665) | 0.01293 | 0.06103 | 88.73 | 385.85 |
| 3 | axon (GO:0030424) | 0.0001190 | 0.002976 | 42.19 | 381.27 |
| 4 | vesicle membrane (GO:0012506) | 0.03591 | 0.09824 | 30.74 | 102.25 |
| 5 | voltage-gated potassium channel complex (GO:0008076) | 0.03591 | 0.09824 | 30.74 | 102.25 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RET | CABOZANTINIB, VANDETANIB |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| SDHC | – |
| SDHAF2 | – |
| MAX | – |
| KIF1B | – |
| ESR1 | CLOMIPHENE, LEVONORGESTREL |
| MEN1 | OLSALAZINE |
| KIT | NILOTINIB, IMATINIB |
| KCNJ5 | – |
