Bowel incontinence (HP:0002607)
Involuntary fecal soiling in adults and children who have usually already been toilet trained.
Synonyms: Faecal incontinence, Loss of bowel control, Anal incontinence, Fecal incontinence
Cross References: MSH:D005242, SNOMEDCT_US:72042002, UMLS:C0015732
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Glycosaminoglycan degradation | 0.009462 | 0.08929 | 123.28 | 574.57 |
| 2 | Tyrosine metabolism | 0.01786 | 0.08929 | 63.35 | 255.00 |
| 3 | Steroid hormone biosynthesis | 0.03009 | 0.09155 | 36.91 | 129.31 |
| 4 | ECM-receptor interaction | 0.04315 | 0.09155 | 25.42 | 79.89 |
| 5 | Hematopoietic cell lineage | 0.04842 | 0.09155 | 22.55 | 68.29 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | middle ear morphogenesis (GO:0042474) | 0.002498 | 0.03291 | 555.17 | 3326.77 |
| 2 | embryonic viscerocranium morphogenesis (GO:0048703) | 0.002498 | 0.03291 | 555.17 | 3326.77 |
| 3 | enamel mineralization (GO:0070166) | 0.002498 | 0.03291 | 555.17 | 3326.77 |
| 4 | coronary artery morphogenesis (GO:0060982) | 0.002498 | 0.03291 | 555.17 | 3326.77 |
| 5 | establishment of planar polarity (GO:0001736) | 0.002997 | 0.03291 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | O-methyltransferase activity (GO:0008171) | 0.004990 | 0.05988 | 246.68 | 1307.49 |
| 2 | hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553) | 0.01835 | 0.07418 | 61.59 | 246.23 |
| 3 | S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) | 0.02130 | 0.07418 | 52.77 | 203.13 |
| 4 | methyltransferase activity (GO:0008168) | 0.02473 | 0.07418 | 45.22 | 167.30 |
| 5 | protein homodimerization activity (GO:0042803) | 0.2762 | 0.4520 | 3.39 | 4.36 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | sarcoplasmic reticulum (GO:0016529) | 0.02228 | 0.1607 | 50.37 | 191.61 |
| 2 | intermediate filament (GO:0005882) | 0.02473 | 0.1607 | 45.22 | 167.30 |
| 3 | intermediate filament cytoskeleton (GO:0045111) | 0.04122 | 0.1786 | 26.65 | 84.98 |
| 4 | intrinsic component of endoplasmic reticulum membrane (GO:0031227) | 0.05889 | 0.1789 | 18.40 | 52.10 |
| 5 | integral component of endoplasmic reticulum membrane (GO:0030176) | 0.06879 | 0.1789 | 15.64 | 41.87 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TBX1 | – |
| VANGL1 | – |
| RTN2 | – |
| FUZ | – |
| LRIG2 | – |
| PLP1 | – |
| HPSE2 | – |
| GP1BB | – |
| C19orf12 | – |
| COMT | ENTACAPONE, OPICAPONE, REMIFENTANIL, SUFENTANIL, MODAFINIL, MORPHINE, METHADONE |
