Abdominal symptom (HP:0011458)
A subjective manifestation of disease localized to the abdomen.
Synonyms: No synonyms found for this term.
Cross References: UMLS:C0740651
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Taste transduction | 0.000009013 | 0.00002704 | 102.79 | 1194.10 |
| 2 | Adrenergic signaling in cardiomyocytes | 0.002417 | 0.003626 | 33.52 | 201.95 |
| 3 | Dopaminergic synapse | 0.06409 | 0.06409 | 16.84 | 46.28 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization during action potential (GO:0086010) | 1.882e-30 | 1.544e-28 | 199740.00 | 13671207.76 |
| 2 | membrane depolarization (GO:0051899) | 2.287e-29 | 9.375e-28 | 199680.00 | 13168480.83 |
| 3 | sodium ion transmembrane transport (GO:0035725) | 1.419e-24 | 2.909e-23 | 199130.00 | 10934655.87 |
| 4 | sodium ion transport (GO:0006814) | 2.029e-24 | 3.327e-23 | 199100.00 | 10861806.72 |
| 5 | inorganic cation transmembrane transport (GO:0098662) | 1.975e-19 | 2.314e-18 | 197260.00 | 8495671.35 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 2.291e-31 | 2.979e-30 | 199780.00 | 14094685.11 |
| 2 | sodium channel activity (GO:0005272) | 1.676e-28 | 1.089e-27 | 199620.00 | 12766920.69 |
| 3 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) | 0.000002248 | 0.000009742 | 1665.58 | 21661.60 |
| 4 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.01038 | 370.07 | 2093.27 |
| 5 | sodium channel inhibitor activity (GO:0019871) | 0.003994 | 0.01038 | 317.19 | 1751.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.889e-33 | 9.645e-32 | 199830.00 | 14798476.21 |
| 2 | sodium channel complex (GO:0034706) | 1.158e-30 | 8.108e-30 | 199750.00 | 13768878.75 |
| 3 | integral component of plasma membrane (GO:0005887) | 4.006e-12 | 1.402e-11 | 185460.00 | 4867070.13 |
| 4 | axon (GO:0030424) | 4.513e-15 | 2.106e-14 | 403.96 | 13343.53 |
| 5 | neuron projection (GO:0043005) | 1.454e-11 | 4.072e-11 | 141.91 | 3541.27 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN2A | – |
| SCN1A | ETHOSUXIMIDE |
| SCN8A | – |
| SCN9A | – |
| SCN5A | INDECAINIDE, BENZONATATE, FOSPHENYTOIN, MORICIZINE, HEXYLCAINE, PROCAINAMIDE, MEXILETINE, DISOPYRAMIDE |
| SCN11A | – |
| SCN10A | HEXYLCAINE, BENZOCAINE, PROPARACAINE, ROPIVACAINE, LEVOBUPIVACAINE, DIBUCAINE, PROCAINE, BENOXINATE, CHLOROPROCAINE |
| SCN1B | ZONISAMIDE |
| SCN4A | LEVOBUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE |
| SCN3A | – |
