Malnutrition (HP:0004395)
A deficiency in the intake of energy and nutrients.
Synonyms: Malnutrition
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Asthma | 0.01540 | 0.07448 | 73.93 | 308.54 |
| 2 | Allograft rejection | 0.01884 | 0.07448 | 59.92 | 237.98 |
| 3 | Graft-versus-host disease | 0.02081 | 0.07448 | 54.06 | 209.35 |
| 4 | Type I diabetes mellitus | 0.02130 | 0.07448 | 52.77 | 203.13 |
| 5 | Carbohydrate digestion and absorption | 0.02326 | 0.07448 | 48.17 | 181.19 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | bone marrow development (GO:0048539) | 0.002498 | 0.03376 | 555.17 | 3326.77 |
| 2 | mature ribosome assembly (GO:0042256) | 0.002498 | 0.03376 | 555.17 | 3326.77 |
| 3 | glucose import across plasma membrane (GO:0098708) | 0.002498 | 0.03376 | 555.17 | 3326.77 |
| 4 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902255) | 0.002498 | 0.03376 | 555.17 | 3326.77 |
| 5 | hexose import across plasma membrane (GO:0140271) | 0.002997 | 0.03376 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glucose:sodium symporter activity (GO:0005412) | 0.003495 | 0.02991 | 370.07 | 2093.27 |
| 2 | ciliary neurotrophic factor receptor binding (GO:0005127) | 0.004492 | 0.02991 | 277.53 | 1500.17 |
| 3 | MHC class II receptor activity (GO:0032395) | 0.004990 | 0.02991 | 246.68 | 1307.49 |
| 4 | carbohydrate:cation symporter activity (GO:0005402) | 0.005985 | 0.02991 | 201.81 | 1032.95 |
| 5 | basic amino acid transmembrane transporter activity (GO:0015174) | 0.006482 | 0.02991 | 184.98 | 932.06 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin filament (GO:0032982) | 0.002997 | 0.07355 | 444.11 | 2580.41 |
| 2 | intracellular vesicle (GO:0097708) | 0.005488 | 0.07355 | 222.00 | 1155.57 |
| 3 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.07355 | 184.98 | 932.06 |
| 4 | supramolecular fiber (GO:0099512) | 0.009462 | 0.07355 | 123.28 | 574.57 |
| 5 | MHC protein complex (GO:0042611) | 0.009957 | 0.07355 | 116.79 | 538.34 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MSX1 | – |
| PVRL1 | – |
| IRF6 | – |
| SBDS | – |
| SLC5A1 | CANAGLIFLOZIN, EMPAGLIFLOZIN, DAPAGLIFLOZIN, ERTUGLIFLOZIN |
| SLC7A7 | – |
| EFTUD1 | – |
| HLA-DQA1 | LAPATINIB, AZATHIOPRINE, MERCAPTOPURINE |
| ACTG2 | – |
| CRLF1 | – |
