Gastroparesis (HP:0002578)
Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction.
Synonyms: Delayed gastric emptying
Cross References: MSH:D018589, SNOMEDCT_US:196753007, SNOMEDCT_US:235675006, UMLS:C0152020
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Various types of N-glycan biosynthesis | 0.01933 | 0.04945 | 58.34 | 230.20 |
| 2 | N-Glycan biosynthesis | 0.02473 | 0.04945 | 45.22 | 167.30 |
| 3 | Vascular smooth muscle contraction | 0.06456 | 0.08608 | 16.72 | 45.80 |
| 4 | Endocytosis | 0.1191 | 0.1191 | 8.74 | 18.59 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial proton-transporting ATP synthase complex assembly (GO:0033615) | 0.002997 | 0.03069 | 444.11 | 2580.41 |
| 2 | proton-transporting ATP synthase complex assembly (GO:0043461) | 0.003495 | 0.03069 | 370.07 | 2093.27 |
| 3 | mitochondrial DNA replication (GO:0006264) | 0.003994 | 0.03069 | 317.19 | 1751.86 |
| 4 | regulation of DNA-directed DNA polymerase activity (GO:1900262) | 0.004492 | 0.03069 | 277.53 | 1500.17 |
| 5 | positive regulation of DNA-directed DNA polymerase activity (GO:1900264) | 0.004492 | 0.03069 | 277.53 | 1500.17 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | aromatic amino acid transmembrane transporter activity (GO:0015173) | 0.004492 | 0.05238 | 277.53 | 1500.17 |
| 2 | DNA polymerase binding (GO:0070182) | 0.008966 | 0.05238 | 130.54 | 615.43 |
| 3 | acetylglucosaminyltransferase activity (GO:0008375) | 0.02375 | 0.05238 | 47.15 | 176.34 |
| 4 | cation transmembrane transporter activity (GO:0008324) | 0.02375 | 0.05238 | 47.15 | 176.34 |
| 5 | manganese ion binding (GO:0030145) | 0.02375 | 0.05238 | 47.15 | 176.34 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin filament (GO:0032982) | 0.002997 | 0.02987 | 444.11 | 2580.41 |
| 2 | U4 snRNP (GO:0005687) | 0.004492 | 0.02987 | 277.53 | 1500.17 |
| 3 | melanosome membrane (GO:0033162) | 0.005985 | 0.02987 | 201.81 | 1032.95 |
| 4 | pigment granule membrane (GO:0090741) | 0.005985 | 0.02987 | 201.81 | 1032.95 |
| 5 | intrinsic component of mitochondrial membrane (GO:0098573) | 0.005985 | 0.02987 | 201.81 | 1032.95 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SNRPN | – |
| MAGEL2 | – |
| OCA2 | – |
| NDN | – |
| C10orf2 | – |
| POLG2 | – |
| DNAJC6 | – |
| ACTG2 | – |
| MGAT2 | – |
| TMEM70 | – |
