Gastric ulcer (HP:0002592)
An ulcer, that is, an erosion of an area of the gastric mucous membrane.
Synonyms: Stomach ulcerComment: The presence of a mucosal erosion equal to or greater than 0.5 cm.
Cross References: MEDDRA:10017822, MSH:D013276, SNOMEDCT_US:397825006, UMLS:C0038358
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hepatocellular carcinoma | 1.664e-18 | 4.992e-18 | 1122.51 | 45952.51 |
| 2 | Thermogenesis | 3.221e-17 | 4.832e-17 | 797.77 | 30294.76 |
| 3 | Transcriptional misregulation in cancer | 0.09198 | 0.09198 | 11.52 | 27.48 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of transcription by RNA polymerase II (GO:0006357) | 2.617e-10 | 2.061e-9 | 177940.00 | 3926054.56 |
| 2 | ATP-dependent chromatin remodeling (GO:0043044) | 8.343e-21 | 5.256e-19 | 2347.76 | 108543.80 |
| 3 | nucleosome disassembly (GO:0006337) | 4.377e-17 | 6.894e-16 | 2497.25 | 94065.34 |
| 4 | chromatin disassembly (GO:0031498) | 4.377e-17 | 6.894e-16 | 2497.25 | 94065.34 |
| 5 | chromatin remodeling (GO:0006338) | 1.773e-20 | 5.584e-19 | 1904.94 | 86635.00 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | nucleosomal DNA binding (GO:0031492) | 2.605e-15 | 5.210e-14 | 1109.06 | 37243.54 |
| 2 | RNA polymerase I core promoter sequence-specific DNA binding (GO:0001164) | 0.000006290 | 0.00004193 | 832.67 | 9972.50 |
| 3 | RNA polymerase I transcription regulatory region sequence-specific DNA binding (GO:0001163) | 0.000006290 | 0.00004193 | 832.67 | 9972.50 |
| 4 | Tat protein binding (GO:0030957) | 0.00001010 | 0.00005052 | 624.44 | 7182.69 |
| 5 | core promoter sequence-specific DNA binding (GO:0001046) | 0.0001485 | 0.0004949 | 142.54 | 1256.48 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | SWI/SNF complex (GO:0016514) | 3.273e-32 | 5.236e-31 | 199810.00 | 14485640.47 |
| 2 | npBAF complex (GO:0071564) | 1.169e-26 | 9.350e-26 | 26649.33 | 1591265.17 |
| 3 | nBAF complex (GO:0071565) | 2.127e-25 | 1.134e-24 | 13322.67 | 756859.90 |
| 4 | Ino80 complex (GO:0031011) | 0.006979 | 0.01396 | 170.74 | 847.70 |
| 5 | H4/H2A histone acetyltransferase complex (GO:0043189) | 0.009462 | 0.01593 | 123.28 | 574.57 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ARID1B | – |
| SMARCA4 | ABEMACICLIB, RIBOCICLIB |
| SMARCC1 | – |
| SMARCA2 | – |
| SMARCB1 | PANOBINOSTAT |
| SMARCC2 | – |
| SMARCD1 | – |
| SMARCE1 | – |
| ACTL6A | – |
| SS18 | – |
