Hypocalcemia (HP:0002901)
An abnormally decreased calcium concentration in the blood.
Synonyms: Low blood calcium levels, Hypocalcaemia
Cross References: MSH:D006996, SNOMEDCT_US:5291005, UMLS:C0020598
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Parathyroid hormone synthesis, secretion and action | 3.963e-12 | 9.115e-11 | 298.35 | 7832.87 |
| 2 | Rheumatoid arthritis | 0.00001141 | 0.0001312 | 94.76 | 1078.51 |
| 3 | Endocrine and other factor-regulated calcium reabsorption | 0.0003059 | 0.002345 | 97.74 | 790.95 |
| 4 | Prolactin signaling pathway | 0.0005336 | 0.003068 | 73.24 | 551.94 |
| 5 | Steroid biosynthesis | 0.009957 | 0.02290 | 116.79 | 538.34 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of prostaglandin secretion (GO:0032308) | 0.000002248 | 0.0002540 | 1665.58 | 21661.60 |
| 2 | positive regulation of fever generation (GO:0031622) | 0.000003371 | 0.0002540 | 1249.13 | 15739.23 |
| 3 | vitamin D metabolic process (GO:0042359) | 4.082e-8 | 0.000009226 | 713.50 | 12139.53 |
| 4 | phosphate ion homeostasis (GO:0055062) | 0.00001010 | 0.0005580 | 624.44 | 7182.69 |
| 5 | positive regulation of bone resorption (GO:0045780) | 0.00001235 | 0.0005580 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.02582 | 555.17 | 3326.77 |
| 2 | bile acid binding (GO:0032052) | 0.004492 | 0.02582 | 277.53 | 1500.17 |
| 3 | tumor necrosis factor-activated receptor activity (GO:0005031) | 0.004492 | 0.02582 | 277.53 | 1500.17 |
| 4 | retinoid X receptor binding (GO:0046965) | 0.005488 | 0.02582 | 222.00 | 1155.57 |
| 5 | death receptor activity (GO:0005035) | 0.005985 | 0.02582 | 201.81 | 1032.95 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Golgi lumen (GO:0005796) | 0.04890 | 0.3423 | 22.32 | 67.37 |
| 2 | endoplasmic reticulum lumen (GO:0005788) | 0.1337 | 0.3763 | 7.71 | 15.51 |
| 3 | integral component of plasma membrane (GO:0005887) | 0.1613 | 0.3763 | 3.19 | 5.82 |
| 4 | endoplasmic reticulum membrane (GO:0005789) | 0.3041 | 0.3960 | 3.01 | 3.59 |
| 5 | intracellular membrane-bounded organelle (GO:0043231) | 0.2469 | 0.3960 | 1.90 | 2.66 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PTH | IBANDRONIC ACID, CLOMIPHENE, CALCITONIN, TRILOSTANE, TERIPARATIDE, PENICILLAMINE, HYDROXYUREA, RANITIDINE |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| VDR | CALCIPOTRIOL, CALCIUM, DIHYDROTACHYSTEROL |
| FGF23 | BUROSUMAB |
| TNFSF11 | DENOSUMAB, LENALIDOMIDE, ANASTROZOLE, LETROZOLE |
| CYP2R1 | CALCIFEDIOL, RIBAVIRIN |
| TBX1 | – |
| DGCR2 | – |
| TNFRSF11A | DICLOFENAC, ACETAMINOPHEN |
| GCM2 | – |
