Increased circulating lactate dehydrogenase concentration (HP:0025435)
An elevated level of the enzyme lactate dehydrogenase in the blood circulation.
Synonyms: Increased lactate dehydrogenase level
Comment: Lactate dehydrogenase catalyzes the interconversion of lactate and pyruvate.
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Vitamin digestion and absorption | 0.01194 | 0.09166 | 96.46 | 427.12 |
| 2 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 0.01293 | 0.09166 | 88.73 | 385.85 |
| 3 | Asthma | 0.01540 | 0.09166 | 73.93 | 308.54 |
| 4 | Allograft rejection | 0.01884 | 0.09166 | 59.92 | 237.98 |
| 5 | Bladder cancer | 0.02032 | 0.09166 | 55.42 | 215.92 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ammonium transport (GO:0015696) | 0.000004719 | 0.0007957 | 999.25 | 12254.80 |
| 2 | ammonium transmembrane transport (GO:0072488) | 0.000006290 | 0.0007957 | 832.67 | 9972.50 |
| 3 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.02804 | 555.17 | 3326.77 |
| 4 | folate transmembrane transport (GO:0098838) | 0.002498 | 0.02804 | 555.17 | 3326.77 |
| 5 | cyclic-GMP-AMP transmembrane import across plasma membrane (GO:0140361) | 0.002498 | 0.02804 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ammonium transmembrane transporter activity (GO:0008519) | 0.00001010 | 0.0003839 | 624.44 | 7182.69 |
| 2 | folic acid transmembrane transporter activity (GO:0008517) | 0.002498 | 0.01582 | 555.17 | 3326.77 |
| 3 | carnitine O-acyltransferase activity (GO:0016406) | 0.002997 | 0.01627 | 444.11 | 2580.41 |
| 4 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.01634 | 317.19 | 1751.86 |
| 5 | dicarboxylic acid transmembrane transporter activity (GO:0005310) | 0.00009070 | 0.001723 | 184.84 | 1720.52 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.05575 | 184.98 | 932.06 |
| 2 | SWI/SNF complex (GO:0016514) | 0.009462 | 0.06117 | 123.28 | 574.57 |
| 3 | MHC protein complex (GO:0042611) | 0.009957 | 0.06117 | 116.79 | 538.34 |
| 4 | lumenal side of endoplasmic reticulum membrane (GO:0098553) | 0.01392 | 0.06648 | 82.15 | 351.18 |
| 5 | integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) | 0.01392 | 0.06648 | 82.15 | 351.18 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ACAD9 | – |
| SLC7A7 | – |
| CPT2 | – |
| SLC25A13 | – |
| RHAG | – |
| SLC19A1 | RALTITREXED, PEMETREXED, LEUCOVORIN |
| RB1 | FOSTAMATINIB, RIBOCICLIB, LORLATINIB |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| RHCE | – |
| PIGA | – |
