Elevated circulating C-reactive protein concentration (HP:0011227)
An abnormal elevation of the C-reactive protein level in the blood circulation.
Synonyms: Elevated C-reactive protein level, Elevated CRP
Comment: C-reactive protein (CRP) is produced by the liver, and increases in concentration in response to inflammation.
Pubmed References: PMID:28722873
Cross References: UMLS:C0742906, UMLS:C4023452
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Influenza A | 0.000001065 | 0.00003395 | 78.66 | 1081.73 |
| 2 | NOD-like receptor signaling pathway | 0.000001306 | 0.00003395 | 74.63 | 1011.07 |
| 3 | Autoimmune thyroid disease | 0.0003059 | 0.003181 | 97.74 | 790.95 |
| 4 | Yersinia infection | 0.00003643 | 0.0006314 | 63.51 | 649.04 |
| 5 | Antigen processing and presentation | 0.0006621 | 0.005738 | 65.51 | 479.51 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 1.191e-7 | 0.00001834 | 475.52 | 7581.26 |
| 2 | regulation of interleukin-4 production (GO:0032673) | 1.586e-7 | 0.00001834 | 427.93 | 6700.13 |
| 3 | detection of bacterium (GO:0016045) | 0.00002041 | 0.0008853 | 416.21 | 4494.85 |
| 4 | positive regulation of cysteine-type endopeptidase activity (GO:2001056) | 1.733e-8 | 0.000006014 | 229.10 | 4094.25 |
| 5 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 0.00002690 | 0.0009334 | 356.71 | 3753.85 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.04205 | 444.11 | 2580.41 |
| 2 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.04205 | 317.19 | 1751.86 |
| 3 | MHC class II receptor activity (GO:0032395) | 0.004990 | 0.04205 | 246.68 | 1307.49 |
| 4 | endopeptidase activator activity (GO:0061133) | 0.004990 | 0.04205 | 246.68 | 1307.49 |
| 5 | caspase binding (GO:0089720) | 0.005985 | 0.04205 | 201.81 | 1032.95 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | early phagosome (GO:0032009) | 0.005985 | 0.04461 | 201.81 | 1032.95 |
| 2 | T cell receptor complex (GO:0042101) | 0.005985 | 0.04461 | 201.81 | 1032.95 |
| 3 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.04461 | 184.98 | 932.06 |
| 4 | MHC protein complex (GO:0042611) | 0.009957 | 0.05548 | 116.79 | 538.34 |
| 5 | clathrin-coated endocytic vesicle (GO:0045334) | 0.0007857 | 0.03064 | 59.96 | 428.66 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NLRC4 | – |
| MEFV | – |
| NLRP3 | ANAKINRA, TRICLOCARBAN |
| PSTPIP1 | – |
| PTPN22 | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| CIITA | – |
| SYK | FOSTAMATINIB |
| PRSS1 | – |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
