Elevated circulating creatine kinase concentration (HP:0003236)
An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood. CK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy.
Synonyms: Elevated blood creatine phosphokinase, Elevated circulating creatine phosphokinase, Elevated creatine kinase, Elevated serum CPK, Elevated serum creatine kinase, Elevated serum creatine phosphokinase, High serum creatine kinase, Increased CPK, Increased creatine kinase, Increased creatine phosphokinase, Increased serum CK, Increased serum creatine kinase, Increased serum creatine phosphokinase
Comment: ‘has part’ some (‘increased amount’ and (‘inheres in’ some (IMR_0002602 and (‘part of’ some blood))) and (‘has modifier’ some abnormal))
Cross References: UMLS:C0151576, UMLS:C0241005
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hypertrophic cardiomyopathy | 1.450e-12 | 1.834e-11 | 355.46 | 9689.66 |
| 2 | Dilated cardiomyopathy | 2.157e-12 | 1.834e-11 | 331.67 | 8909.27 |
| 3 | Cardiac muscle contraction | 6.874e-8 | 3.895e-7 | 159.90 | 2637.14 |
| 4 | Viral myocarditis | 0.000003034 | 0.00001032 | 149.87 | 1904.21 |
| 5 | Adrenergic signaling in cardiomyocytes | 6.163e-7 | 0.000002619 | 90.61 | 1295.71 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | actin-myosin filament sliding (GO:0033275) | 3.458e-21 | 2.403e-19 | 2661.33 | 125385.00 |
| 2 | muscle filament sliding (GO:0030049) | 3.458e-21 | 2.403e-19 | 2661.33 | 125385.00 |
| 3 | heart contraction (GO:0060047) | 6.755e-21 | 3.130e-19 | 2419.03 | 112349.58 |
| 4 | cardiac muscle contraction (GO:0060048) | 2.534e-18 | 8.804e-17 | 1725.20 | 69899.68 |
| 5 | cardiac muscle tissue morphogenesis (GO:0055008) | 2.132e-15 | 3.704e-14 | 1151.77 | 38908.86 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | FATZ binding (GO:0051373) | 0.000002248 | 0.00001476 | 1665.58 | 21661.60 |
| 2 | titin binding (GO:0031432) | 2.567e-8 | 6.161e-7 | 856.29 | 14966.03 |
| 3 | myosin heavy chain binding (GO:0032036) | 0.000004719 | 0.00002265 | 999.25 | 12254.80 |
| 4 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.01198 | 370.07 | 2093.27 |
| 5 | telethonin binding (GO:0031433) | 0.003495 | 0.01198 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 8.995e-10 | 1.169e-8 | 4283.14 | 89214.48 |
| 2 | myofibril (GO:0030016) | 7.595e-13 | 1.975e-11 | 907.64 | 25328.60 |
| 3 | muscle myosin complex (GO:0005859) | 0.00002354 | 0.0002040 | 384.17 | 4094.01 |
| 4 | myosin filament (GO:0032982) | 0.002997 | 0.01113 | 444.11 | 2580.41 |
| 5 | pseudopodium (GO:0031143) | 0.004492 | 0.01460 | 277.53 | 1500.17 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TCAP | – |
| LDB3 | – |
| CSRP3 | – |
| MYH6 | – |
| DMD | ETEPLIRSEN, ATALUREN |
| MYL2 | – |
| ACTN2 | – |
| MYBPC3 | – |
| TNNI3 | – |
| MYH7 | – |
