Elevated circulating alanine aminotransferase concentration (HP:0031964)
An abnormally high concentration in the circulation of alanine aminotransferase (ALT).
Synonyms: Elevated serum ALT, Alanine aminotransferase increased, Elevated serum alanine aminotransferase, Elevated serum glutamic-pyruvic transaminase
Comment: Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells.
Pubmed References: PMID:18366115
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Taurine and hypotaurine metabolism | 0.005488 | 0.03490 | 222.00 | 1155.57 |
| 2 | Bile secretion | 0.00001034 | 0.0001344 | 98.04 | 1125.55 |
| 3 | Primary bile acid biosynthesis | 0.008469 | 0.03490 | 138.71 | 661.82 |
| 4 | Maturity onset diabetes of the young | 0.01293 | 0.03490 | 88.73 | 385.85 |
| 5 | Biosynthesis of unsaturated fatty acids | 0.01342 | 0.03490 | 85.32 | 367.79 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | bile acid secretion (GO:0032782) | 0.002498 | 0.03435 | 555.17 | 3326.77 |
| 2 | fructose transmembrane transport (GO:0015755) | 0.002498 | 0.03435 | 555.17 | 3326.77 |
| 3 | dehydroascorbic acid transport (GO:0070837) | 0.002997 | 0.03435 | 444.11 | 2580.41 |
| 4 | cellular triglyceride homeostasis (GO:0035356) | 0.002997 | 0.03435 | 444.11 | 2580.41 |
| 5 | positive regulation of protein glycosylation (GO:0060050) | 0.002997 | 0.03435 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | fructose transmembrane transporter activity (GO:0005353) | 0.002498 | 0.02631 | 555.17 | 3326.77 |
| 2 | dehydroascorbic acid transmembrane transporter activity (GO:0033300) | 0.002997 | 0.02631 | 444.11 | 2580.41 |
| 3 | L-aspartate transmembrane transporter activity (GO:0015183) | 0.004492 | 0.02631 | 277.53 | 1500.17 |
| 4 | bile acid binding (GO:0032052) | 0.004492 | 0.02631 | 277.53 | 1500.17 |
| 5 | L-glutamate transmembrane transporter activity (GO:0005313) | 0.006979 | 0.02631 | 170.74 | 847.70 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | anchored component of external side of plasma membrane (GO:0031362) | 0.009957 | 0.05883 | 116.79 | 538.34 |
| 2 | intrinsic component of external side of plasma membrane (GO:0031233) | 0.01194 | 0.05883 | 96.46 | 427.12 |
| 3 | myofibril (GO:0030016) | 0.01342 | 0.05883 | 85.32 | 367.79 |
| 4 | intrinsic component of mitochondrial inner membrane (GO:0031304) | 0.01933 | 0.05883 | 58.34 | 230.20 |
| 5 | anchored component of plasma membrane (GO:0046658) | 0.02277 | 0.05883 | 49.25 | 186.27 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NR1H4 | OBETICHOLIC ACID, CHENODIOL |
| BAAT | – |
| SLC51B | – |
| SLC2A2 | METFORMIN |
| SLC25A13 | – |
| SCO1 | – |
| DAK | – |
| TTC26 | – |
| KIF12 | – |
| PKHD1 | – |
