Decreased circulating calcifediol concentration (HP:0012053)
A reduced concentration of calcifediol in the blood. Calcifediol is also known as calcidiol, 25-hydroxycholecalciferol and 25-Hydroxyvitamin D3.
Synonyms: Decreased 25-hydroxyvitamin D3, Low serum 25-hydroxycholecalciferol, Low serum calcidiol, Low serum calcifediol
Cross References: UMLS:C4023064
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Drug metabolism | 4.444e-12 | 7.111e-11 | 292.47 | 7645.02 |
| 2 | Retinol metabolism | 9.725e-11 | 7.780e-10 | 316.30 | 7291.95 |
| 3 | Linoleic acid metabolism | 3.266e-7 | 7.466e-7 | 329.08 | 4914.57 |
| 4 | Steroid hormone biosynthesis | 1.622e-8 | 6.487e-8 | 233.13 | 4181.78 |
| 5 | Metabolism of xenobiotics by cytochrome P450 | 3.973e-8 | 1.271e-7 | 184.43 | 3142.85 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | monoterpenoid metabolic process (GO:0016098) | 1.799e-9 | 6.954e-8 | 2855.29 | 57494.92 |
| 2 | terpenoid metabolic process (GO:0006721) | 3.147e-9 | 9.125e-8 | 2141.36 | 41921.23 |
| 3 | lipid hydroxylation (GO:0002933) | 0.000004719 | 0.00006082 | 999.25 | 12254.80 |
| 4 | estrogen metabolic process (GO:0008210) | 8.580e-10 | 4.976e-8 | 511.90 | 10686.61 |
| 5 | regulation of anion transport (GO:0044070) | 0.000006290 | 0.00007296 | 832.67 | 9972.50 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | estrogen 2-hydroxylase activity (GO:0101021) | 0.000002248 | 0.00004271 | 1665.58 | 21661.60 |
| 2 | estrogen 16-alpha-hydroxylase activity (GO:0101020) | 0.000006290 | 0.00007681 | 832.67 | 9972.50 |
| 3 | retinoic acid 4-hydroxylase activity (GO:0008401) | 0.000008085 | 0.00007681 | 713.68 | 8368.26 |
| 4 | steroid hydroxylase activity (GO:0008395) | 1.841e-9 | 6.998e-8 | 415.79 | 8362.69 |
| 5 | arachidonic acid epoxygenase activity (GO:0008392) | 0.00002690 | 0.0001704 | 356.71 | 3753.85 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | external side of apical plasma membrane (GO:0098591) | 0.002498 | 0.01249 | 555.17 | 3326.77 |
| 2 | endoplasmic reticulum membrane (GO:0005789) | 3.704e-7 | 0.000003704 | 40.97 | 606.74 |
| 3 | lipid droplet (GO:0005811) | 0.03785 | 0.09462 | 29.11 | 95.32 |
| 4 | mitochondrial outer membrane (GO:0005741) | 0.06126 | 0.1146 | 17.66 | 49.31 |
| 5 | organelle outer membrane (GO:0031968) | 0.06879 | 0.1146 | 15.64 | 41.87 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CYP3A4 | – |
| CYP2C9 | – |
| CYP2C19 | – |
| ABCB1 | – |
| CYP3A7 | MICONAZOLE, QUININE, ETONOGESTREL, COBICISTAT |
| UGT2B7 | EFAVIRENZ, FLURBIPROFEN, APREPITANT |
| UGT1A8 | FEBUXOSTAT |
| POR | TACROLIMUS |
| CYB5A | – |
| CES1 | CLOPIDOGREL, TRANDOLAPRIL, DIACETYLMORPHINE |
