Abnormal circulating protein concentration (HP:0010876)
An abnormal level of a circulating protein in the blood.
Synonyms: Blood protein disease, Abnormal circulating protein level, Abnormality of circulating protein level, Serum protein abnormality
Cross References: UMLS:C4020763, UMLS:C4020764, UMLS:C4023679
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hypertrophic cardiomyopathy | 1.450e-12 | 1.834e-11 | 355.46 | 9689.66 |
| 2 | Dilated cardiomyopathy | 2.157e-12 | 1.834e-11 | 331.67 | 8909.27 |
| 3 | Cardiac muscle contraction | 6.874e-8 | 3.895e-7 | 159.90 | 2637.14 |
| 4 | Viral myocarditis | 0.000003034 | 0.00001032 | 149.87 | 1904.21 |
| 5 | Adrenergic signaling in cardiomyocytes | 6.163e-7 | 0.000002619 | 90.61 | 1295.71 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | actin-myosin filament sliding (GO:0033275) | 3.458e-21 | 2.403e-19 | 2661.33 | 125385.00 |
| 2 | muscle filament sliding (GO:0030049) | 3.458e-21 | 2.403e-19 | 2661.33 | 125385.00 |
| 3 | heart contraction (GO:0060047) | 6.755e-21 | 3.130e-19 | 2419.03 | 112349.58 |
| 4 | cardiac muscle contraction (GO:0060048) | 2.534e-18 | 8.804e-17 | 1725.20 | 69899.68 |
| 5 | cardiac muscle tissue morphogenesis (GO:0055008) | 2.132e-15 | 3.704e-14 | 1151.77 | 38908.86 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | FATZ binding (GO:0051373) | 0.000002248 | 0.00001476 | 1665.58 | 21661.60 |
| 2 | titin binding (GO:0031432) | 2.567e-8 | 6.161e-7 | 856.29 | 14966.03 |
| 3 | myosin heavy chain binding (GO:0032036) | 0.000004719 | 0.00002265 | 999.25 | 12254.80 |
| 4 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.01198 | 370.07 | 2093.27 |
| 5 | telethonin binding (GO:0031433) | 0.003495 | 0.01198 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 8.995e-10 | 1.169e-8 | 4283.14 | 89214.48 |
| 2 | myofibril (GO:0030016) | 7.595e-13 | 1.975e-11 | 907.64 | 25328.60 |
| 3 | muscle myosin complex (GO:0005859) | 0.00002354 | 0.0002040 | 384.17 | 4094.01 |
| 4 | myosin filament (GO:0032982) | 0.002997 | 0.01113 | 444.11 | 2580.41 |
| 5 | pseudopodium (GO:0031143) | 0.004492 | 0.01460 | 277.53 | 1500.17 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TCAP | – |
| LDB3 | – |
| CSRP3 | – |
| MYH6 | – |
| MYL2 | – |
| DMD | ETEPLIRSEN, ATALUREN |
| ACTN2 | – |
| MYBPC3 | – |
| TNNI3 | – |
| MYH7 | – |
