Impairment of activities of daily living (HP:0031058)
Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.
Synonyms: No synonyms found for this term.
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 0.01983 | 0.1019 | 56.84 | 222.86 |
| 2 | Non-small cell lung cancer | 0.03543 | 0.1019 | 31.17 | 104.12 |
| 3 | Taste transduction | 0.04219 | 0.1019 | 26.02 | 82.37 |
| 4 | GABAergic synapse | 0.04363 | 0.1019 | 25.13 | 78.70 |
| 5 | Morphine addiction | 0.04459 | 0.1019 | 24.57 | 76.41 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic vesicle transport (GO:0048489) | 0.00001235 | 0.0003498 | 555.03 | 6273.06 |
| 2 | synaptic vesicle localization (GO:0097479) | 0.00001750 | 0.0003718 | 454.07 | 4973.59 |
| 3 | anterograde dendritic transport (GO:0098937) | 0.002498 | 0.01769 | 555.17 | 3326.77 |
| 4 | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) | 0.002498 | 0.01769 | 555.17 | 3326.77 |
| 5 | establishment of vesicle localization (GO:0051650) | 0.00003428 | 0.0005827 | 312.09 | 3208.63 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | gap junction channel activity involved in cell communication by electrical coupling (GO:1903763) | 0.002997 | 0.02309 | 444.11 | 2580.41 |
| 2 | benzodiazepine receptor activity (GO:0008503) | 0.004990 | 0.02309 | 246.68 | 1307.49 |
| 3 | extracellular ligand-gated ion channel activity (GO:0005230) | 0.005488 | 0.02309 | 222.00 | 1155.57 |
| 4 | GABA-gated chloride ion channel activity (GO:0022851) | 0.006482 | 0.02309 | 184.98 | 932.06 |
| 5 | inhibitory extracellular ligand-gated ion channel activity (GO:0005237) | 0.006979 | 0.02309 | 170.74 | 847.70 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endoplasmic reticulum tubular network membrane (GO:0098826) | 0.002498 | 0.04559 | 555.17 | 3326.77 |
| 2 | GABA-A receptor complex (GO:1902711) | 0.009462 | 0.04559 | 123.28 | 574.57 |
| 3 | connexin complex (GO:0005922) | 0.01045 | 0.04559 | 110.94 | 506.01 |
| 4 | endoplasmic reticulum tubular network (GO:0071782) | 0.01144 | 0.04559 | 100.85 | 450.83 |
| 5 | gap junction (GO:0005921) | 0.01194 | 0.04559 | 96.46 | 427.12 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KIF5A | – |
| KIAA0196 | – |
| RTN2 | – |
| NIPA1 | – |
| SPG11 | – |
| SPAST | – |
| ATL1 | – |
| GJC2 | CARBENOXOLONE |
| PLP1 | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
