Pedal edema (HP:0010741)
An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.
Synonyms: Lower leg swelling, Leg oedema, Oedema of the lower limbs, Pedal oedema, Peripheral oedema of lower extremity, Dependant oedema, Fluid accumulation in lower limbs, Edema of the lower limbs, Leg edema, Peripheral edema of lower extremity, Dependant edema
Cross References: SNOMEDCT_US:102572006, UMLS:C0235886, UMLS:C0239340
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone signaling pathway | 0.001583 | 0.01940 | 41.75 | 269.21 |
| 2 | cGMP-PKG signaling pathway | 0.002985 | 0.01940 | 30.04 | 174.65 |
| 3 | Viral myocarditis | 0.02960 | 0.07791 | 37.53 | 132.12 |
| 4 | Lysine degradation | 0.03106 | 0.07791 | 35.71 | 123.99 |
| 5 | Cardiac muscle contraction | 0.04267 | 0.07791 | 25.72 | 81.12 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of cardioblast differentiation (GO:0051891) | 0.000002248 | 0.00003414 | 1665.58 | 21661.60 |
| 2 | regulation of cardioblast differentiation (GO:0051890) | 0.000002248 | 0.00003414 | 1665.58 | 21661.60 |
| 3 | cardiac atrium morphogenesis (GO:0003209) | 1.217e-10 | 2.956e-8 | 887.78 | 20267.77 |
| 4 | atrial septum morphogenesis (GO:0060413) | 1.482e-8 | 0.000001200 | 1070.46 | 19297.66 |
| 5 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 0.000003371 | 0.00004819 | 1249.13 | 15739.23 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | aromatic amino acid transmembrane transporter activity (GO:0015173) | 0.004492 | 0.01206 | 277.53 | 1500.17 |
| 2 | co-SMAD binding (GO:0070410) | 0.004990 | 0.01206 | 246.68 | 1307.49 |
| 3 | histone methyltransferase activity (H3-K36 specific) (GO:0046975) | 0.005488 | 0.01224 | 222.00 | 1155.57 |
| 4 | lysine N-methyltransferase activity (GO:0016278) | 0.01045 | 0.02165 | 110.94 | 506.01 |
| 5 | transcription regulatory region nucleic acid binding (GO:0001067) | 0.0001334 | 0.001634 | 40.56 | 361.91 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | U4 snRNP (GO:0005687) | 0.004492 | 0.01971 | 277.53 | 1500.17 |
| 2 | melanosome membrane (GO:0033162) | 0.005985 | 0.01971 | 201.81 | 1032.95 |
| 3 | U2-type catalytic step 1 spliceosome (GO:0071006) | 0.005985 | 0.01971 | 201.81 | 1032.95 |
| 4 | pigment granule membrane (GO:0090741) | 0.005985 | 0.01971 | 201.81 | 1032.95 |
| 5 | chitosome (GO:0045009) | 0.005985 | 0.01971 | 201.81 | 1032.95 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NKX2-5 | – |
| TBX20 | – |
| MYH6 | – |
| GATA4 | WARFARIN |
| GATA6 | – |
| SNRPN | – |
| SETD2 | – |
| MAGEL2 | – |
| OCA2 | – |
| RBM8A | – |
