Red eye (HP:0025337)
A reddish appearance over the white part (sclera) of the eye ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera.
Synonyms: Red eye, Red eyes
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 5.941e-18 | 8.317e-17 | 1502.29 | 59587.92 |
| 2 | B cell receptor signaling pathway | 2.384e-10 | 1.669e-9 | 262.03 | 5805.76 |
| 3 | Intestinal immune network for IgA production | 0.0002507 | 0.0008775 | 108.39 | 898.70 |
| 4 | Epstein-Barr virus infection | 0.0001156 | 0.0005395 | 42.62 | 386.39 |
| 5 | Hematopoietic cell lineage | 0.001064 | 0.002736 | 51.27 | 351.00 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lymphocyte differentiation (GO:0030098) | 9.479e-13 | 4.589e-11 | 382.92 | 10601.05 |
| 2 | B cell activation (GO:0042113) | 1.020e-12 | 4.589e-11 | 378.06 | 10438.72 |
| 3 | B cell receptor signaling pathway (GO:0050853) | 1.451e-9 | 3.264e-8 | 443.56 | 9026.96 |
| 4 | B cell differentiation (GO:0030183) | 5.558e-11 | 1.667e-9 | 355.96 | 8405.46 |
| 5 | V(D)J recombination (GO:0033151) | 0.00001235 | 0.0001587 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) | 0.0001327 | 0.004379 | 151.19 | 1349.73 |
| 2 | phospholipase activator activity (GO:0016004) | 0.005488 | 0.03290 | 222.00 | 1155.57 |
| 3 | complement receptor activity (GO:0004875) | 0.005488 | 0.03290 | 222.00 | 1155.57 |
| 4 | lipase activator activity (GO:0060229) | 0.005985 | 0.03290 | 201.81 | 1032.95 |
| 5 | phospholipase binding (GO:0043274) | 0.006979 | 0.03290 | 170.74 | 847.70 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | pericentric heterochromatin (GO:0005721) | 0.006979 | 0.02443 | 170.74 | 847.70 |
| 2 | multivesicular body (GO:0005771) | 0.02326 | 0.05427 | 48.17 | 181.19 |
| 3 | membrane raft (GO:0045121) | 0.002846 | 0.01992 | 30.79 | 180.49 |
| 4 | late endosome (GO:0005770) | 0.09060 | 0.1586 | 11.70 | 28.10 |
| 5 | integral component of plasma membrane (GO:0005887) | 0.1613 | 0.2258 | 3.19 | 5.82 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CD19 | BLINATUMOMAB |
| CD79A | – |
| CD79B | POLATUZUMAB VEDOTIN |
| CR2 | PROGESTERONE |
| BTK | IBRUTINIB |
| TNFRSF13C | – |
| TNFRSF13B | – |
| RAG1 | – |
| RAG2 | – |
| IKZF1 | LENALIDOMIDE |
