Gaze-evoked nystagmus (HP:0000640)
Nystagmus made apparent by looking to the right or to the left.
Synonyms: No synonyms found for this term.
Cross References: MSH:D009760, SNOMEDCT_US:29356006, UMLS:C0271390
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Spinocerebellar ataxia | 2.465e-11 | 1.874e-9 | 217.37 | 5309.47 |
| 2 | Aldosterone-regulated sodium reabsorption | 0.0001485 | 0.002821 | 142.54 | 1256.48 |
| 3 | Aldosterone synthesis and secretion | 0.00001335 | 0.0005074 | 89.75 | 1007.36 |
| 4 | Endocrine and other factor-regulated calcium reabsorption | 0.0003059 | 0.004649 | 97.74 | 790.95 |
| 5 | GnRH secretion | 0.0004462 | 0.005651 | 80.35 | 619.92 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization during action potential (GO:0086010) | 4.685e-10 | 7.550e-8 | 605.09 | 12998.28 |
| 2 | cardiac muscle cell action potential (GO:0086001) | 8.580e-10 | 7.550e-8 | 511.90 | 10686.61 |
| 3 | neuronal action potential (GO:0019228) | 1.379e-7 | 0.000006068 | 450.47 | 7115.97 |
| 4 | membrane depolarization (GO:0051899) | 4.430e-7 | 0.00001559 | 294.99 | 4315.59 |
| 5 | membrane repolarization (GO:0086009) | 0.00002690 | 0.0004734 | 356.71 | 3753.85 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 1.379e-7 | 0.000005517 | 450.47 | 7115.97 |
| 2 | sodium channel activity (GO:0005272) | 7.523e-7 | 0.00001505 | 244.35 | 3445.31 |
| 3 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007) | 0.002498 | 0.01869 | 555.17 | 3326.77 |
| 4 | P-type sodium transporter activity (GO:0008554) | 0.002997 | 0.01869 | 444.11 | 2580.41 |
| 5 | P-type sodium:potassium-exchanging transporter activity (GO:0005391) | 0.002997 | 0.01869 | 444.11 | 2580.41 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.098e-8 | 0.000001829 | 611.51 | 10158.88 |
| 2 | nuclear inclusion body (GO:0042405) | 0.00001235 | 0.00009259 | 555.03 | 6273.06 |
| 3 | sodium channel complex (GO:0034706) | 2.058e-7 | 0.000003087 | 388.99 | 5988.96 |
| 4 | sodium:potassium-exchanging ATPase complex (GO:0005890) | 0.004990 | 0.02138 | 246.68 | 1307.49 |
| 5 | cation-transporting ATPase complex (GO:0090533) | 0.007973 | 0.02658 | 147.96 | 714.91 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ATXN10 | – |
| PRKCG | – |
| ATXN1 | – |
| ATXN2 | – |
| ATXN3 | – |
| CACNA1G | ETHOSUXIMIDE, ZONISAMIDE, TRIMETHADIONE, METHSUXIMIDE, PARAMETHADIONE, FLUNARIZINE, PHENSUXIMIDE |
| SCN8A | – |
| SCN1A | ETHOSUXIMIDE |
| KCND3 | – |
| ATP1A2 | ACETYLDIGITOXIN, DESLANOSIDE |
