Blurred vision (HP:0000622)
Lack of sharpness of vision resulting in the inability to see fine detail.
Synonyms: Blurred vision
Comment: This is a very nonspecific term and it is preferable to describe the correlates of blurred vision with the corresponding terms if possible.
Cross References: SNOMEDCT_US:111516008, SNOMEDCT_US:246636008, UMLS:C0344232
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Proximal tubule bicarbonate reclamation | 0.01144 | 0.06159 | 100.85 | 450.83 |
| 2 | Collecting duct acid secretion | 0.01342 | 0.06159 | 85.32 | 367.79 |
| 3 | Protein digestion and absorption | 0.001151 | 0.02416 | 49.23 | 333.17 |
| 4 | Aldosterone-regulated sodium reabsorption | 0.01835 | 0.06159 | 61.59 | 246.23 |
| 5 | Carbohydrate digestion and absorption | 0.02326 | 0.06159 | 48.17 | 181.19 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuronal action potential (GO:0019228) | 1.379e-7 | 0.00001605 | 450.47 | 7115.97 |
| 2 | membrane depolarization during action potential (GO:0086010) | 2.326e-7 | 0.00001605 | 372.06 | 5682.76 |
| 3 | regulation of muscle system process (GO:0090257) | 0.00001481 | 0.0002555 | 499.50 | 5554.53 |
| 4 | regulation of respiratory gaseous exchange by nervous system process (GO:0002087) | 0.002498 | 0.01929 | 555.17 | 3326.77 |
| 5 | negative regulation of keratinocyte differentiation (GO:0045617) | 0.002498 | 0.01929 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.01946 | 555.17 | 3326.77 |
| 2 | P-type sodium transporter activity (GO:0008554) | 0.002997 | 0.01946 | 444.11 | 2580.41 |
| 3 | P-type sodium:potassium-exchanging transporter activity (GO:0005391) | 0.002997 | 0.01946 | 444.11 | 2580.41 |
| 4 | sodium ion binding (GO:0031402) | 0.002997 | 0.01946 | 444.11 | 2580.41 |
| 5 | voltage-gated sodium channel activity (GO:0005248) | 0.00005170 | 0.002016 | 249.63 | 2463.82 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 0.00003048 | 0.0007010 | 332.92 | 3461.84 |
| 2 | sodium channel complex (GO:0034706) | 0.00006709 | 0.0007715 | 217.03 | 2085.58 |
| 3 | sodium:potassium-exchanging ATPase complex (GO:0005890) | 0.004990 | 0.01913 | 246.68 | 1307.49 |
| 4 | cation-transporting ATPase complex (GO:0090533) | 0.007973 | 0.02620 | 147.96 | 714.91 |
| 5 | basement membrane (GO:0005604) | 0.02570 | 0.06697 | 43.44 | 159.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KCNA1 | BUPIVACAINE, ISOFLURANE, DESFLURANE |
| SCN9A | – |
| SCN4A | LEVOBUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE |
| ATP1A2 | ACETYLDIGITOXIN, DESLANOSIDE |
| SPATA7 | – |
| COL8A2 | – |
| VSX1 | – |
| CLCNKB | – |
| GRHL2 | – |
| RPE65 | – |
