Dysphonia (HP:0001618)
An impairment in the ability to produce voice sounds.
Synonyms: Voice change, Inability to produce voice sounds
Cross References: MSH:D055154, SNOMEDCT_US:47004009, UMLS:C1527344
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Citrate cycle (TCA cycle) | 0.01490 | 0.08712 | 76.48 | 321.69 |
| 2 | Cholinergic synapse | 0.001382 | 0.03456 | 44.77 | 294.78 |
| 3 | Thyroid cancer | 0.01835 | 0.08712 | 61.59 | 246.23 |
| 4 | Mitophagy | 0.03349 | 0.08712 | 33.04 | 112.22 |
| 5 | Central carbon metabolism in cancer | 0.03446 | 0.08712 | 32.08 | 108.04 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860) | 0.002498 | 0.04559 | 555.17 | 3326.77 |
| 2 | positive regulation of vascular associated smooth muscle cell apoptotic process (GO:1905461) | 0.002498 | 0.04559 | 555.17 | 3326.77 |
| 3 | Schwann cell differentiation (GO:0014037) | 0.002498 | 0.04559 | 555.17 | 3326.77 |
| 4 | neuromuscular synaptic transmission (GO:0007274) | 0.00004255 | 0.009105 | 277.39 | 2791.90 |
| 5 | astrocyte development (GO:0014002) | 0.002997 | 0.04559 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533) | 0.002498 | 0.04791 | 555.17 | 3326.77 |
| 2 | O-acetyltransferase activity (GO:0016413) | 0.003994 | 0.04791 | 317.19 | 1751.86 |
| 3 | phosphatidylethanolamine binding (GO:0008429) | 0.004492 | 0.04791 | 277.53 | 1500.17 |
| 4 | organic cation transmembrane transporter activity (GO:0015101) | 0.007973 | 0.06378 | 147.96 | 714.91 |
| 5 | kinesin binding (GO:0019894) | 0.01441 | 0.07433 | 79.21 | 335.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | clathrin coat of endocytic vesicle (GO:0030128) | 0.003495 | 0.01592 | 370.07 | 2093.27 |
| 2 | AP-1 adaptor complex (GO:0030121) | 0.003495 | 0.01592 | 370.07 | 2093.27 |
| 3 | AP-2 adaptor complex (GO:0030122) | 0.003495 | 0.01592 | 370.07 | 2093.27 |
| 4 | clathrin coat of trans-Golgi network vesicle (GO:0030130) | 0.004492 | 0.01842 | 277.53 | 1500.17 |
| 5 | clathrin coat of coated pit (GO:0030132) | 0.004990 | 0.01860 | 246.68 | 1307.49 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MAX | – |
| SDHC | – |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| KIF1B | – |
| RET | CABOZANTINIB, VANDETANIB |
| SDHAF2 | – |
| SYT2 | – |
| CHAT | RIVASTIGMINE, GALANTAMINE, DONEPEZILM PILOCARPINE |
| SLC18A3 | – |
| MFN2 | – |
