Abnormality of the pharynx (HP:0000600)
An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly.
Synonyms: No synonyms found for this term.
Comment: The pharynx is tubular structure extending from base of skull superiorly to esophageal inlet inferiorly, and is composed of three distinct areas: the nasopharynx, the oropharynx, and the hypopharynx, with the pharyngeal walls being composed of the superior, middle, and inferior pharyngeal constrictor muscles. It is part of the digestive system and of the conducting zone of the respiratory system.
Cross References: UMLS:C4025838
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Huntington disease | 0.009682 | 0.02024 | 16.19 | 75.08 |
| 2 | Amyotrophic lateral sclerosis | 0.01350 | 0.02024 | 13.56 | 58.36 |
| 3 | Pathways of neurodegeneration | 0.02233 | 0.02233 | 10.32 | 39.22 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | axonemal dynein complex assembly (GO:0070286) | 1.125e-9 | 1.305e-8 | 475.29 | 9793.38 |
| 2 | axoneme assembly (GO:0035082) | 1.451e-9 | 1.305e-8 | 443.56 | 9026.96 |
| 3 | outer dynein arm assembly (GO:0036158) | 0.00003428 | 0.0001234 | 312.09 | 3208.63 |
| 4 | cilium movement (GO:0003341) | 0.000001964 | 0.00001178 | 174.41 | 2291.88 |
| 5 | determination of bilateral symmetry (GO:0009855) | 0.00009070 | 0.0002721 | 184.84 | 1720.52 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | motor activity (GO:0003774) | 0.0004745 | 0.001423 | 77.84 | 595.70 |
| 2 | microtubule motor activity (GO:0003777) | 0.02766 | 0.04148 | 40.27 | 144.50 |
| 3 | nucleoside-triphosphatase activity (GO:0017111) | 0.1306 | 0.1306 | 7.91 | 16.09 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | outer dynein arm (GO:0036157) | 0.000008085 | 0.00008893 | 713.68 | 8368.26 |
| 2 | motile cilium (GO:0031514) | 0.0005036 | 0.001847 | 75.47 | 573.09 |
| 3 | cilium (GO:0005929) | 0.0001854 | 0.001020 | 36.18 | 310.92 |
| 4 | sperm flagellum (GO:0036126) | 0.02570 | 0.06192 | 43.44 | 159.04 |
| 5 | 9+2 motile cilium (GO:0097729) | 0.02814 | 0.06192 | 39.55 | 141.22 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RSPH4A | – |
| HEATR2 | – |
| RSPH1 | – |
| SPAG1 | – |
| DYX1C1 | – |
| C21orf59 | – |
| CCDC65 | – |
| HYDIN | – |
| DNAI2 | – |
| DNAI1 | – |
