Ear pain (HP:0030766)
Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).
Synonyms: Ear pain, Pain in the ear, Otalgia
Pubmed References: PMID:20736106
Cross References: MSH:D004433, SNOMEDCT_US:16001004, SNOMEDCT_US:162356005, UMLS:C0013456
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hedgehog signaling pathway | 0.0001147 | 0.004940 | 184.63 | 1675.22 |
| 2 | Basal cell carcinoma | 0.0001453 | 0.004940 | 163.39 | 1443.80 |
| 3 | Pathways in cancer | 0.000007064 | 0.0007205 | 73.88 | 876.24 |
| 4 | Aldosterone-regulated sodium reabsorption | 0.01105 | 0.06141 | 110.88 | 499.54 |
| 5 | Gastric cancer | 0.0008109 | 0.02050 | 67.51 | 480.47 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | establishment of protein localization to telomere (GO:0070200) | 0.001499 | 0.01866 | 999.50 | 6499.56 |
| 2 | determination of left/right asymmetry in lateral mesoderm (GO:0003140) | 0.001499 | 0.01866 | 999.50 | 6499.56 |
| 3 | contact inhibition (GO:0060242) | 0.001799 | 0.01866 | 799.56 | 5053.71 |
| 4 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 0.001799 | 0.01866 | 799.56 | 5053.71 |
| 5 | negative regulation of actin filament depolymerization (GO:0030835) | 0.001799 | 0.01866 | 799.56 | 5053.71 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | RNA-directed DNA polymerase activity (GO:0003964) | 0.001799 | 0.01416 | 799.56 | 5053.71 |
| 2 | telomerase activity (GO:0003720) | 0.001799 | 0.01416 | 799.56 | 5053.71 |
| 3 | patched binding (GO:0005113) | 0.002098 | 0.01416 | 666.27 | 4108.59 |
| 4 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.002098 | 0.01416 | 666.27 | 4108.59 |
| 5 | 1-phosphatidylinositol-3-kinase activity (GO:0016303) | 0.002997 | 0.01481 | 444.11 | 2580.41 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.001499 | 0.02697 | 999.50 | 6499.56 |
| 2 | transferase complex, transferring phosphorus-containing groups (GO:0061695) | 0.002697 | 0.02697 | 499.65 | 2955.69 |
| 3 | intercalated disc (GO:0014704) | 0.009265 | 0.03706 | 133.09 | 623.08 |
| 4 | ciliary membrane (GO:0060170) | 0.009265 | 0.03706 | 133.09 | 623.08 |
| 5 | cell-cell contact zone (GO:0044291) | 0.01402 | 0.04180 | 86.73 | 370.11 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SMO | VISMODEGIB, SONIDEGIB, GLASDEGIB, POSACONAZOLE, SONIDEGIB PHOSPHATE |
| PIK3CA | – |
| SUFU | SONIDEGIB |
| TERT | OMACETAXINE MEPESUCCINATE |
| KRT6A | – |
| TRAF7 | – |
