Recurrent fever (HP:0001954)
Periodic (episodic or recurrent) bouts of fever.
Synonyms: Episodic fever, Increased body temperature, episodic, Intermittent fever, Hyperthermia, episodic
Cross References: SNOMEDCT_US:77957000, UMLS:C0277799
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NOD-like receptor signaling pathway | 1.030e-10 | 5.666e-9 | 169.84 | 3905.74 |
| 2 | C-type lectin receptor signaling pathway | 0.00001596 | 0.0004389 | 84.39 | 932.17 |
| 3 | Yersinia infection | 0.00003643 | 0.0006678 | 63.51 | 649.04 |
| 4 | Fc gamma R-mediated phagocytosis | 0.001021 | 0.01075 | 52.36 | 360.55 |
| 5 | NF-kappa B signaling pathway | 0.001173 | 0.01075 | 48.75 | 328.95 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of killing of cells of other organism (GO:0051712) | 0.000003371 | 0.00009468 | 1249.13 | 15739.23 |
| 2 | negative regulation of interleukin-1 production (GO:0032692) | 3.628e-7 | 0.00001359 | 316.87 | 4699.01 |
| 3 | positive regulation of superoxide anion generation (GO:0032930) | 0.00002041 | 0.0005289 | 416.21 | 4494.85 |
| 4 | positive regulation of cysteine-type endopeptidase activity (GO:2001056) | 1.733e-8 | 0.000003461 | 229.10 | 4094.25 |
| 5 | positive regulation of cell killing (GO:0031343) | 0.00002354 | 0.0005289 | 384.17 | 4094.01 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endopeptidase activator activity (GO:0061133) | 0.004990 | 0.03381 | 246.68 | 1307.49 |
| 2 | caspase binding (GO:0089720) | 0.005985 | 0.03381 | 201.81 | 1032.95 |
| 3 | phosphatidate phosphatase activity (GO:0008195) | 0.006482 | 0.03381 | 184.98 | 932.06 |
| 4 | phospholipase binding (GO:0043274) | 0.006979 | 0.03381 | 170.74 | 847.70 |
| 5 | protein kinase C activity (GO:0004697) | 0.006979 | 0.03381 | 170.74 | 847.70 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cytolytic granule (GO:0044194) | 0.003495 | 0.02155 | 370.07 | 2093.27 |
| 2 | early phagosome (GO:0032009) | 0.005985 | 0.02155 | 201.81 | 1032.95 |
| 3 | T cell receptor complex (GO:0042101) | 0.005985 | 0.02155 | 201.81 | 1032.95 |
| 4 | endolysosome (GO:0036019) | 0.01243 | 0.03730 | 92.44 | 405.55 |
| 5 | spindle microtubule (GO:0005876) | 0.03009 | 0.06771 | 36.91 | 129.31 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NLRC4 | – |
| MEFV | – |
| NLRP3 | ANAKINRA, TRICLOCARBAN |
| NLRP12 | – |
| SYK | FOSTAMATINIB |
| XIAP | ETOPOSIDE PHOSPHATE |
| LPIN2 | – |
| PRF1 | EMAPALUMAB |
| PRKCD | – |
| TMEM173 | – |
