Pancreatitis (HP:0001733)
The presence of inflammation in the pancreas.
Synonyms: Pancreatic inflammation
Cross References: MSH:D010195, SNOMEDCT_US:75694006, UMLS:C0030305
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Sulfur relay system | 0.003994 | 0.01864 | 317.19 | 1751.86 |
| 2 | Propanoate metabolism | 0.0001252 | 0.001752 | 155.92 | 1401.11 |
| 3 | Valine, leucine and isoleucine degradation | 0.0002507 | 0.001755 | 108.39 | 898.70 |
| 4 | Thiamine metabolism | 0.007476 | 0.02617 | 158.54 | 776.21 |
| 5 | Autoimmune thyroid disease | 0.02619 | 0.07247 | 42.60 | 155.17 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of toll-like receptor 9 signaling pathway (GO:0034165) | 0.002498 | 0.02080 | 555.17 | 3326.77 |
| 2 | negative regulation of regulatory T cell differentiation (GO:0045590) | 0.002498 | 0.02080 | 555.17 | 3326.77 |
| 3 | branched-chain amino acid catabolic process (GO:0009083) | 0.00004255 | 0.001616 | 277.39 | 2791.90 |
| 4 | branched-chain amino acid metabolic process (GO:0009081) | 0.00004255 | 0.001616 | 277.39 | 2791.90 |
| 5 | cobalamin metabolic process (GO:0009235) | 0.00004701 | 0.001616 | 262.78 | 2618.60 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (GO:0016624) | 0.000004719 | 0.00009909 | 999.25 | 12254.80 |
| 2 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.01573 | 444.11 | 2580.41 |
| 3 | sulfurtransferase activity (GO:0016783) | 0.003994 | 0.01677 | 317.19 | 1751.86 |
| 4 | carboxy-lyase activity (GO:0016831) | 0.01144 | 0.02901 | 100.85 | 450.83 |
| 5 | phosphatidylinositol phospholipase C activity (GO:0004435) | 0.01144 | 0.02901 | 100.85 | 450.83 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | mitochondrial alpha-ketoglutarate dehydrogenase complex (GO:0005947) | 0.000002248 | 0.00003147 | 1665.58 | 21661.60 |
| 2 | mitochondrial matrix (GO:0005759) | 0.0005723 | 0.004006 | 24.40 | 182.19 |
| 3 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.09509 | 41.02 | 147.91 |
| 4 | clathrin-coated vesicle (GO:0030136) | 0.03930 | 0.09731 | 28.00 | 90.64 |
| 5 | clathrin-coated endocytic vesicle (GO:0045334) | 0.04171 | 0.09731 | 26.33 | 83.66 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| CTRC | – |
| PRSS1 | – |
| PRSS3P2 | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| BCKDHB | – |
| PTPN22 | – |
| BCKDHA | – |
| G6PC | – |
| NFS1 | – |
