Menorrhagia (HP:0000132)
Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
Synonyms: Abnormally heavy periods, Abnormally heavy bleeding during menstruation, Hypermenorrhea
Pubmed References: PMID:22594864
Cross References: MSH:D008595, SNOMEDCT_US:386692008, UMLS:C0025323
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Platelet activation | 1.731e-7 | 0.00001454 | 132.47 | 2062.51 |
| 2 | ECM-receptor interaction | 0.000006783 | 0.0002708 | 117.09 | 1393.55 |
| 3 | Hematopoietic cell lineage | 0.000009671 | 0.0002708 | 103.62 | 1196.43 |
| 4 | Dilated cardiomyopathy | 0.0008030 | 0.01686 | 60.48 | 431.03 |
| 5 | Vasopressin-regulated water reabsorption | 0.01963 | 0.09128 | 57.99 | 227.93 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endosome to melanosome transport (GO:0035646) | 0.000006469 | 0.0003170 | 815.67 | 9746.03 |
| 2 | endosome to pigment granule transport (GO:0043485) | 0.000006469 | 0.0003170 | 815.67 | 9746.03 |
| 3 | anterograde synaptic vesicle transport (GO:0048490) | 0.00001884 | 0.0004292 | 439.08 | 4776.89 |
| 4 | synaptic vesicle transport along microtubule (GO:0099517) | 0.00001884 | 0.0004292 | 439.08 | 4776.89 |
| 5 | negative regulation of blood coagulation, intrinsic pathway (GO:2000267) | 0.002248 | 0.01185 | 624.59 | 3808.55 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | leukemia inhibitory factor receptor activity (GO:0004923) | 0.002697 | 0.01112 | 499.65 | 2955.69 |
| 2 | oncostatin-M receptor activity (GO:0004924) | 0.002697 | 0.01112 | 499.65 | 2955.69 |
| 3 | ciliary neurotrophic factor receptor activity (GO:0004897) | 0.003595 | 0.01112 | 356.86 | 2008.48 |
| 4 | ciliary neurotrophic factor receptor binding (GO:0005127) | 0.004043 | 0.01112 | 312.23 | 1720.62 |
| 5 | protein kinase A regulatory subunit binding (GO:0034237) | 0.009858 | 0.02169 | 118.87 | 549.11 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | platelet alpha granule membrane (GO:0031092) | 0.007625 | 0.06100 | 156.05 | 760.96 |
| 2 | platelet alpha granule (GO:0031091) | 0.0007063 | 0.01130 | 64.62 | 468.85 |
| 3 | endosome lumen (GO:0031904) | 0.01164 | 0.06209 | 99.83 | 444.56 |
| 4 | endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116) | 0.02184 | 0.08498 | 51.93 | 198.60 |
| 5 | platelet alpha granule lumen (GO:0031093) | 0.02975 | 0.08498 | 37.74 | 132.64 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GP9 | – |
| GP1BB | – |
| ITGA2B | TIROFIBAN, ABCIXIMAB, EPTIFIBATIDE, THROMBIN |
| F8 | SORBITOL, RANITIDINE |
| BLOC1S5 | – |
| SLFN14 | – |
| BLOC1S3 | – |
| PRKACG | – |
| PRLR | SOMATROPIN |
