Hypothermia (HP:0002045)
Reduced body temperature due to failed thermoregulation.
Synonyms: Hypothermia, Abnormally low body temperature
Comment: A condition in which core temperature drops below that required for normal metabolism and body functions which is defined as 35.0 degrees C (95.0 degrees F).
Cross References: MSH:D007035, SNOMEDCT_US:386689009, UMLS:C0020672
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone synthesis | 1.608e-10 | 1.447e-9 | 284.57 | 6417.37 |
| 2 | Autoimmune thyroid disease | 9.117e-9 | 4.103e-8 | 271.31 | 5022.72 |
| 3 | Regulation of lipolysis in adipocytes | 0.0003294 | 0.0009883 | 94.04 | 754.04 |
| 4 | Citrate cycle (TCA cycle) | 0.01490 | 0.02009 | 76.48 | 321.69 |
| 5 | Propanoate metabolism | 0.01687 | 0.02009 | 67.20 | 274.29 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | thyroid hormone generation (GO:0006590) | 1.975e-8 | 0.000001007 | 951.48 | 16879.14 |
| 2 | response to gonadotropin (GO:0034698) | 0.002997 | 0.02206 | 444.11 | 2580.41 |
| 3 | cellular response to gonadotropin stimulus (GO:0071371) | 0.003495 | 0.02206 | 370.07 | 2093.27 |
| 4 | thyroid gland development (GO:0030878) | 0.003994 | 0.02206 | 317.19 | 1751.86 |
| 5 | embryonic hemopoiesis (GO:0035162) | 0.006482 | 0.02755 | 184.98 | 932.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | anion:sodium symporter activity (GO:0015373) | 0.002498 | 0.01310 | 555.17 | 3326.77 |
| 2 | symporter activity (GO:0015293) | 0.004990 | 0.01310 | 246.68 | 1307.49 |
| 3 | methyl-CpG binding (GO:0008327) | 0.01194 | 0.02507 | 96.46 | 427.12 |
| 4 | inorganic anion transmembrane transporter activity (GO:0015103) | 0.01441 | 0.02751 | 79.21 | 335.86 |
| 5 | sequence-specific DNA binding (GO:0043565) | 0.0002742 | 0.005758 | 18.29 | 150.01 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | extracellular membrane-bounded organelle (GO:0065010) | 0.02766 | 0.1310 | 40.27 | 144.50 |
| 2 | extracellular vesicle (GO:1903561) | 0.02912 | 0.1310 | 38.18 | 135.03 |
| 3 | basolateral plasma membrane (GO:0016323) | 0.07300 | 0.2150 | 14.70 | 38.46 |
| 4 | vesicle (GO:0031982) | 0.1074 | 0.2150 | 9.76 | 21.77 |
| 5 | mitochondrial matrix (GO:0005759) | 0.1610 | 0.2150 | 6.29 | 11.49 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TSHB | MESTRANOL, LEVOTHYROXINE, BACLOFEN |
| TG | ACEBUTOLOL, AMINOGLETETHIMIDE |
| TPO | CARBIMAZOLE, METHIMAZOLE, PROPYLTHIOURACIL |
| TSHR | THYROTROPIN ALFA |
| POU1F1 | – |
| PROP1 | – |
| LHX4 | – |
| SLC5A5 | – |
| LHX3 | – |
| SUCLG1 | – |
