Heat intolerance (HP:0002046)
The inability to maintain a comfortable body temperature in warm or hot weather.
Synonyms: Heat intolerance, Intolerance to heat and fevers
Comment: Heat intolerance tends to produce a feeling of being overheated and profuse diaphoresis (sweating). Many, but not all, cases of heat intolerance are related to thyrotoxicosis.
Cross References: SNOMEDCT_US:69215007, UMLS:C0231274
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NF-kappa B signaling pathway | 0.00001596 | 0.0009258 | 84.39 | 932.17 |
| 2 | Other types of O-glycan biosynthesis | 0.02326 | 0.1047 | 48.17 | 181.19 |
| 3 | Viral carcinogenesis | 0.004372 | 0.1047 | 24.61 | 133.71 |
| 4 | Long-term depression | 0.02960 | 0.1047 | 37.53 | 132.12 |
| 5 | GnRH secretion | 0.03155 | 0.1047 | 35.14 | 121.47 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of low-density lipoprotein receptor activity (GO:1905599) | 0.002498 | 0.05769 | 555.17 | 3326.77 |
| 2 | progesterone receptor signaling pathway (GO:0050847) | 0.003994 | 0.06070 | 317.19 | 1751.86 |
| 3 | regulation of low-density lipoprotein particle clearance (GO:0010988) | 0.004990 | 0.06320 | 246.68 | 1307.49 |
| 4 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 0.00002215 | 0.001683 | 75.39 | 807.99 |
| 5 | odontogenesis of dentin-containing tooth (GO:0042475) | 0.007973 | 0.07527 | 147.96 | 714.91 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | aromatic amino acid transmembrane transporter activity (GO:0015173) | 0.004492 | 0.04235 | 277.53 | 1500.17 |
| 2 | inositol 1,4,5 trisphosphate binding (GO:0070679) | 0.005488 | 0.04235 | 222.00 | 1155.57 |
| 3 | fucosyltransferase activity (GO:0008417) | 0.005985 | 0.04235 | 201.81 | 1032.95 |
| 4 | death receptor binding (GO:0005123) | 0.007476 | 0.04235 | 158.54 | 776.21 |
| 5 | calcium-release channel activity (GO:0015278) | 0.008469 | 0.04235 | 138.71 | 661.82 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | platelet dense tubular network membrane (GO:0031095) | 0.004492 | 0.03352 | 277.53 | 1500.17 |
| 2 | platelet dense tubular network (GO:0031094) | 0.005488 | 0.03352 | 222.00 | 1155.57 |
| 3 | melanosome membrane (GO:0033162) | 0.005985 | 0.03352 | 201.81 | 1032.95 |
| 4 | pigment granule membrane (GO:0090741) | 0.005985 | 0.03352 | 201.81 | 1032.95 |
| 5 | chitosome (GO:0045009) | 0.005985 | 0.03352 | 201.81 | 1032.95 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| EDAR | – |
| OCA2 | – |
| EDA | – |
| EDARADD | – |
| UBE3A | – |
| POFUT1 | – |
| ITPR2 | – |
| CLDN10 | – |
| HNRNPK | – |
| LBX1 | – |
