Decreased glomerular filtration rate (HP:0012213)
An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman’s capsules per unit of time.
Synonyms: Decreased GFR, Impaired renal creatinine clearance, Reduced creatinine clearance
Comment: Renal clearance is defined as the volume of plasma per minute needed to excrete the quantity of a solute appearing in the urine in a minute. Normal values for adults are 97 to 137 ml/min (male) and 88 to 128 ml/min (female). This term refers to a reduction below normal limits in the ability of the kidney to clear creatinine from the bloodstream.
Pubmed References: PMID:25710660
Cross References: UMLS:C0853068
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Collecting duct acid secretion | 0.01342 | 0.08282 | 85.32 | 367.79 |
| 2 | Tyrosine metabolism | 0.01786 | 0.08282 | 63.35 | 255.00 |
| 3 | Arrhythmogenic right ventricular cardiomyopathy | 0.03785 | 0.08282 | 29.11 | 95.32 |
| 4 | ECM-receptor interaction | 0.04315 | 0.08282 | 25.42 | 79.89 |
| 5 | Hypertrophic cardiomyopathy | 0.04411 | 0.08282 | 24.85 | 77.54 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | urate metabolic process (GO:0046415) | 0.00001235 | 0.0002551 | 555.03 | 6273.06 |
| 2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 3 | L-phenylalanine catabolic process (GO:0006559) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 4 | urate transport (GO:0015747) | 0.002498 | 0.02532 | 555.17 | 3326.77 |
| 5 | tyrosine catabolic process (GO:0006572) | 0.002997 | 0.02532 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | urate transmembrane transporter activity (GO:0015143) | 0.000002248 | 0.00004244 | 1665.58 | 21661.60 |
| 2 | voltage-gated chloride channel activity (GO:0005247) | 0.00001010 | 0.00007746 | 624.44 | 7182.69 |
| 3 | voltage-gated anion channel activity (GO:0008308) | 0.00002690 | 0.0001547 | 356.71 | 3753.85 |
| 4 | carbohydrate:proton symporter activity (GO:0005351) | 0.003495 | 0.01608 | 370.07 | 2093.27 |
| 5 | chloride channel activity (GO:0005254) | 0.000003690 | 0.00004244 | 140.02 | 1751.57 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | filopodium membrane (GO:0031527) | 0.005985 | 0.01995 | 201.81 | 1032.95 |
| 2 | excitatory synapse (GO:0060076) | 0.01243 | 0.02585 | 92.44 | 405.55 |
| 3 | cell projection membrane (GO:0031253) | 0.0009195 | 0.004598 | 55.28 | 386.48 |
| 4 | synaptic membrane (GO:0097060) | 0.01293 | 0.02585 | 88.73 | 385.85 |
| 5 | brush border membrane (GO:0031526) | 0.01835 | 0.03058 | 61.59 | 246.23 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| BSND | – |
| CLCNKB | – |
| CLCNKA | – |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| SLC22A12 | LESINURAD, SULFINPYRAZONE |
| SLC2A9 | – |
| G6PC | – |
| ITGA3 | – |
| SLC7A7 | – |
| HGD | – |
