Petechiae (HP:0000967)
Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.
Synonyms: No synonyms found for this term.
Pubmed References: PMID:29493956
Cross References: MEDDRA:10034754, MSH:D011693, SNOMEDCT_US:271813007, SNOMEDCT_US:50091001, UMLS:C0031256
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Platelet activation | 2.872e-7 | 0.00001120 | 110.39 | 1662.81 |
| 2 | ECM-receptor interaction | 0.000009659 | 0.0001790 | 100.36 | 1158.94 |
| 3 | Hematopoietic cell lineage | 0.00001377 | 0.0001790 | 88.81 | 994.11 |
| 4 | Allograft rejection | 0.01884 | 0.09536 | 59.92 | 237.98 |
| 5 | Graft-versus-host disease | 0.02081 | 0.09536 | 54.06 | 209.35 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of glycoprotein metabolic process (GO:1903018) | 0.002498 | 0.02593 | 555.17 | 3326.77 |
| 2 | extracellular exosome biogenesis (GO:0097734) | 0.002498 | 0.02593 | 555.17 | 3326.77 |
| 3 | positive regulation of killing of cells of other organism (GO:0051712) | 0.002997 | 0.02593 | 444.11 | 2580.41 |
| 4 | taurine metabolic process (GO:0019530) | 0.002997 | 0.02593 | 444.11 | 2580.41 |
| 5 | positive regulation of erythrocyte differentiation (GO:0045648) | 0.00007845 | 0.003662 | 199.65 | 1887.30 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glucocorticoid receptor binding (GO:0035259) | 0.004492 | 0.04040 | 277.53 | 1500.17 |
| 2 | C2H2 zinc finger domain binding (GO:0070742) | 0.005985 | 0.04040 | 201.81 | 1032.95 |
| 3 | syntaxin-1 binding (GO:0017075) | 0.01095 | 0.04795 | 105.66 | 476.99 |
| 4 | wide pore channel activity (GO:0022829) | 0.01243 | 0.04795 | 92.44 | 405.55 |
| 5 | channel activity (GO:0015267) | 0.02277 | 0.06147 | 49.25 | 186.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cytolytic granule (GO:0044194) | 0.000004719 | 0.0001557 | 999.25 | 12254.80 |
| 2 | multivesicular body membrane (GO:0032585) | 0.004492 | 0.02139 | 277.53 | 1500.17 |
| 3 | primary lysosome (GO:0005766) | 0.005488 | 0.02139 | 222.00 | 1155.57 |
| 4 | melanosome membrane (GO:0033162) | 0.005985 | 0.02139 | 201.81 | 1032.95 |
| 5 | pigment granule membrane (GO:0090741) | 0.005985 | 0.02139 | 201.81 | 1032.95 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ITGA2B | TIROFIBAN, ABCIXIMAB, EPTIFIBATIDE, THROMBIN |
| GATA1 | CYTARABINE, DAUNORUBICIN |
| GP9 | – |
| STAT5B | TOFACITINIB, DASATINIB, EPOETIN ALFA |
| PRF1 | EMAPALUMAB |
| STXBP2 | EMAPALUMAB |
| GP1BB | – |
| GFI1B | – |
| RAB27A | EMAPALUMAB |
| FERMT3 | – |
