Stroke (HP:0001297)
Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain.
Synonyms: Stroke, Cerebral vascular events, Cerebrovascular accident, Cerebrovascular accidents
Cross References: MSH:D020521, SNOMEDCT_US:230690007, UMLS:C0038454
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hypertrophic cardiomyopathy | 0.00001034 | 0.0001569 | 98.04 | 1125.55 |
| 2 | Dilated cardiomyopathy | 0.00001255 | 0.0001569 | 91.69 | 1034.81 |
| 3 | Adrenergic signaling in cardiomyocytes | 0.00004774 | 0.0003978 | 57.85 | 575.61 |
| 4 | cGMP-PKG signaling pathway | 0.00006572 | 0.0004108 | 51.81 | 498.94 |
| 5 | Cardiac muscle contraction | 0.0008229 | 0.004114 | 58.54 | 415.82 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of cardioblast differentiation (GO:0051891) | 0.000002248 | 0.00002290 | 1665.58 | 21661.60 |
| 2 | regulation of cardioblast differentiation (GO:0051890) | 0.000002248 | 0.00002290 | 1665.58 | 21661.60 |
| 3 | cardiac atrium morphogenesis (GO:0003209) | 1.217e-10 | 6.691e-9 | 887.78 | 20267.77 |
| 4 | cardiac muscle tissue morphogenesis (GO:0055008) | 1.893e-12 | 5.205e-10 | 739.37 | 19957.87 |
| 5 | atrial septum morphogenesis (GO:0060413) | 1.482e-8 | 2.911e-7 | 1070.46 | 19297.66 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) | 0.002498 | 0.01463 | 555.17 | 3326.77 |
| 2 | myosin heavy chain binding (GO:0032036) | 0.003495 | 0.01463 | 370.07 | 2093.27 |
| 3 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.01463 | 370.07 | 2093.27 |
| 4 | co-SMAD binding (GO:0070410) | 0.004990 | 0.01463 | 246.68 | 1307.49 |
| 5 | calcium channel inhibitor activity (GO:0019855) | 0.005488 | 0.01463 | 222.00 | 1155.57 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 0.000002248 | 0.00002361 | 1665.58 | 21661.60 |
| 2 | myofibril (GO:0030016) | 2.616e-7 | 0.000005494 | 356.54 | 5403.81 |
| 3 | muscle myosin complex (GO:0005859) | 0.007476 | 0.04446 | 158.54 | 776.21 |
| 4 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.04446 | 138.71 | 661.82 |
| 5 | sodium channel complex (GO:0034706) | 0.01243 | 0.04619 | 92.44 | 405.55 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NKX2-5 | – |
| MYH6 | – |
| TNNI3 | – |
| SCN5A | INDECAINIDE, BENZONATATE, FOSPHENYTOIN, MORICIZINE, HEXYLCAINE, PROCAINAMIDE, MEXILETINE, DISOPYRAMIDE |
| NPPA | CLORTHALIDONE, AMLODIPINE |
| GATA4 | WARFARIN |
| TBX20 | – |
| MYBPC3 | – |
| ACTA2 | – |
| COL3A1 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
