LONG COVID-Cardiovascular finding-Hypertension

Hypertension (HP:0000822)

The presence of chronic increased pressure in the systemic arterial system.

Synonyms:    High blood pressure, Arterial hypertension, Systemic hypertension

Comment:    Hypertension is sustained elevation of resting systolic BP (140 mm Hg or higher), diastolic BP (90 mm Hg or higher), or both.

Cross References:    MSH:D006973, SNOMEDCT_US:24184005, SNOMEDCT_US:38341003, UMLS:C0020538, UMLS:C0497247

GO: Biological Process

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1cilium assembly (GO:0060271)5.098e-163.568e-14580.8720453.89
2pigment granule transport (GO:0051904)7.315e-88.534e-7570.719377.24
3melanosome transport (GO:0032402)7.315e-88.534e-7570.719377.24
4establishment of melanosome localization (GO:0032401)8.685e-88.685e-7535.028698.92
5melanosome localization (GO:0032400)1.191e-70.000001042475.527581.26

GO: Molecular Function

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1patched binding (GO:0005113)0.0034950.006990370.072093.27
2RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)1.780e-88.402e-8107.051910.30
3DNA-binding transcription factor binding (GO:0140297)2.801e-88.402e-897.471695.14
4phosphatidylinositol-3-phosphate binding (GO:0032266)0.019330.0290058.34230.20
5phosphatidylinositol phosphate binding (GO:1901981)0.049860.0598321.8865.61

GO: Cellular Component

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1motile cilium (GO:0031514)0.033490.0669833.04112.22
2neuron projection (GO:0043005)0.029940.066988.7730.77
3cilium (GO:0005929)0.11240.12769.3020.33
4cell-cell junction (GO:0005911)0.12760.12768.1216.71

Hub genes predicted as biomarkers & predicted FDA approved drugs

Hub Genes (ranked)FDA-Approved Drugs
BBS1–
BBS2–
MKS1–
SDCCAG8–
BBS5–
BBS7–
BBS12–
BBS10–
WDPCP         –
CCDC28B–