Increased circulating troponin I concentration (HP:0410173)
An increased concentration of tropnin I in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.
Synonyms: Increased troponin I level in blood
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Vibrio cholerae infection | 0.0002721 | 0.003227 | 103.86 | 852.65 |
| 2 | Viral myocarditis | 0.0003921 | 0.003227 | 85.91 | 673.90 |
| 3 | Adherens junction | 0.0005489 | 0.003227 | 72.18 | 541.87 |
| 4 | Gastric acid secretion | 0.0006287 | 0.003227 | 67.28 | 496.00 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy | 0.0006453 | 0.003227 | 66.38 | 487.64 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | protein localization to membrane raft (GO:1903044) | 0.000002248 | 0.0003131 | 1665.58 | 21661.60 |
| 2 | membrane raft assembly (GO:0001765) | 0.000003371 | 0.0003131 | 1249.13 | 15739.23 |
| 3 | regulation of toll-like receptor 3 signaling pathway (GO:0034139) | 0.000006290 | 0.0003560 | 832.67 | 9972.50 |
| 4 | morphogenesis of a polarized epithelium (GO:0001738) | 0.00001481 | 0.0006986 | 499.50 | 5554.53 |
| 5 | membrane raft organization (GO:0031579) | 0.00002354 | 0.0007403 | 384.17 | 4094.01 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.002498 | 0.03992 | 555.17 | 3326.77 |
| 2 | nitric-oxide synthase binding (GO:0050998) | 0.003495 | 0.03992 | 370.07 | 2093.27 |
| 3 | histone demethylase activity (H3-K4 specific) (GO:0032453) | 0.004492 | 0.03992 | 277.53 | 1500.17 |
| 4 | Tat protein binding (GO:0030957) | 0.004990 | 0.03992 | 246.68 | 1307.49 |
| 5 | histone demethylase activity (H3-K9 specific) (GO:0032454) | 0.006482 | 0.04445 | 184.98 | 932.06 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | flotillin complex (GO:0016600) | 0.000002248 | 0.00001911 | 1665.58 | 21661.60 |
| 2 | actin cytoskeleton (GO:0015629) | 2.954e-9 | 1.004e-7 | 95.23 | 1870.24 |
| 3 | cortical actin cytoskeleton (GO:0030864) | 0.0001917 | 0.0008146 | 124.69 | 1067.29 |
| 4 | cell-cell contact zone (GO:0044291) | 0.0002403 | 0.0008171 | 110.81 | 923.40 |
| 5 | focal adhesion (GO:0005925) | 6.150e-7 | 0.000007616 | 51.33 | 734.10 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SVIL | – |
| ACTB | ETHINYL ESTRADIOL, CYCLOPHOSPHAMIDE |
| KDM1A | TRANYLCYPROMINE |
| ACTG1 | VINCRISTINE |
| FLOT2 | – |
| FLOT1 | – |
| AR | – |
| NEB | – |
| POTEF | – |
| KIF14 | – |
