Bradycardia (HP:0001662)
A slower than normal heart rate (in adults, slower than 60 beats per minute).
Synonyms: Slow heartbeats, Brachycardia
Cross References: MSH:D001919, SNOMEDCT_US:48867003, UMLS:C0428977
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Cardiac muscle contraction | 0.000009332 | 0.0004106 | 101.56 | 1176.29 |
| 2 | GnRH secretion | 0.0004462 | 0.006544 | 80.35 | 619.92 |
| 3 | Circadian entrainment | 0.001021 | 0.009173 | 52.36 | 360.55 |
| 4 | Aldosterone synthesis and secretion | 0.001042 | 0.009173 | 51.81 | 355.72 |
| 5 | Calcium signaling pathway | 0.0001924 | 0.004233 | 35.72 | 305.61 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization during SA node cell action potential (GO:0086046) | 1.574e-13 | 1.286e-11 | 13326.00 | 392846.55 |
| 2 | SA node cell action potential (GO:0086015) | 1.102e-12 | 4.498e-11 | 4441.56 | 122294.78 |
| 3 | SA node cell to atrial cardiac muscle cell signaling (GO:0086018) | 8.995e-10 | 1.224e-8 | 4283.14 | 89214.48 |
| 4 | cardiac muscle cell action potential (GO:0086001) | 1.397e-15 | 3.423e-13 | 1247.88 | 42682.61 |
| 5 | regulation of cardiac muscle cell membrane repolarization (GO:0099623) | 2.480e-13 | 1.519e-11 | 1174.88 | 34101.37 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 1.379e-7 | 0.000005103 | 450.47 | 7115.97 |
| 2 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) | 0.00001481 | 0.0001370 | 499.50 | 5554.53 |
| 3 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) | 0.00002354 | 0.0001742 | 384.17 | 4094.01 |
| 4 | sodium channel activity (GO:0005272) | 7.523e-7 | 0.00001392 | 244.35 | 3445.31 |
| 5 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007) | 0.002498 | 0.007701 | 555.17 | 3326.77 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | junctional sarcoplasmic reticulum membrane (GO:0014701) | 0.000008085 | 0.00008624 | 713.68 | 8368.26 |
| 2 | voltage-gated sodium channel complex (GO:0001518) | 0.00003048 | 0.0002438 | 332.92 | 3461.84 |
| 3 | sarcolemma (GO:0042383) | 0.000001964 | 0.00006284 | 174.41 | 2291.88 |
| 4 | sodium channel complex (GO:0034706) | 0.00006709 | 0.0004294 | 217.03 | 2085.58 |
| 5 | sarcoplasmic reticulum membrane (GO:0033017) | 0.00008446 | 0.0004505 | 191.96 | 1800.45 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN5A | INDECAINIDE, BENZONATATE, FOSPHENYTOIN, MORICIZINE, HEXYLCAINE, PROCAINAMIDE, MEXILETINE, DISOPYRAMIDE |
| ANK2 | – |
| CAV3 | – |
| CASQ2 | – |
| KCNE2 | – |
| HCN4 | IVABRADINE HYDROCHLORIDE, DRONEDARONE HYDROCHLORIDE, IVABRADINE |
| KCNJ5 | – |
| SCN10A | HEXYLCAINE, BENZOCAINE, PROPARACAINE, ROPIVACAINE, LEVOBUPIVACAINE, DIBUCAINE, PROCAINE, BENOXINATE, CHLOROPROCAINE |
| TRDN | – |
| CACNA1D | ISRADIPINE, CLEVIDIPINE, NIMODIPINE, NITRENDIPINE |
