Exertional dyspnea (HP:0002875)
Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest.
Synonyms: Exertional breathlessness, Shortness of breathing upon physical activity, Exertional dyspnoea
Pubmed References: PMID:29763022
Cross References: SNOMEDCT_US:60845006, UMLS:C0231807
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Neuroactive ligand-receptor interaction | 0.00001608 | 0.00001608 | 38.88 | 429.14 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic transmission, cholinergic (GO:0007271) | 1.217e-10 | 1.594e-8 | 887.78 | 20267.77 |
| 2 | neuromuscular junction development (GO:0007528) | 1.812e-7 | 0.000006289 | 407.53 | 6326.45 |
| 3 | regulation of cardioblast differentiation (GO:0051890) | 0.002498 | 0.02180 | 555.17 | 3326.77 |
| 4 | positive regulation of cardioblast differentiation (GO:0051891) | 0.002498 | 0.02180 | 555.17 | 3326.77 |
| 5 | ventricular cardiac muscle cell differentiation (GO:0055012) | 0.002498 | 0.02180 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099529) | 1.878e-10 | 6.009e-9 | 783.25 | 17541.62 |
| 2 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) | 8.580e-10 | 1.373e-8 | 511.90 | 10686.61 |
| 3 | transmitter-gated ion channel activity (GO:0022824) | 1.451e-9 | 1.547e-8 | 443.56 | 9026.96 |
| 4 | postsynaptic neurotransmitter receptor activity (GO:0098960) | 1.191e-7 | 8.827e-7 | 475.52 | 7581.26 |
| 5 | acetylcholine receptor activity (GO:0015464) | 1.379e-7 | 8.827e-7 | 450.47 | 7115.97 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuromuscular junction (GO:0031594) | 4.712e-12 | 5.654e-11 | 604.76 | 15772.67 |
| 2 | acetylcholine-gated channel complex (GO:0005892) | 3.267e-8 | 1.960e-7 | 778.40 | 13417.28 |
| 3 | ion channel complex (GO:0034702) | 5.841e-7 | 0.000002337 | 267.29 | 3836.51 |
| 4 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.01694 | 138.71 | 661.82 |
| 5 | neuron projection (GO:0043005) | 0.000003661 | 0.00001098 | 35.28 | 441.62 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RAPSN | – |
| CHRNA1 | – |
| SCN4A | LEVOBUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE |
| CHRNE | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHRND | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| COLQ | – |
| CHRNB1 | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| DOK7 | – |
| MUSK | – |
| NKX2-5 | – |
