Pleural thickening (HP:0031944)
An increase in the thickness of the pleura, generally related to scarring of the pleural tissue.
Synonyms: Pleural incrassation
Pubmed References: PMID:23287997
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NF-kappa B signaling pathway | 1.941e-20 | 2.212e-18 | 1884.79 | 85548.22 |
| 2 | B cell receptor signaling pathway | 2.384e-10 | 1.359e-8 | 262.03 | 5805.76 |
| 3 | T cell receptor signaling pathway | 8.515e-10 | 3.236e-8 | 200.92 | 4196.00 |
| 4 | Shigellosis | 6.478e-8 | 0.000001846 | 81.95 | 1356.40 |
| 5 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 0.000009993 | 0.0002278 | 99.19 | 1142.03 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | activation of NF-kappaB-inducing kinase activity (GO:0007250) | 5.717e-11 | 1.927e-9 | 1109.89 | 26176.78 |
| 2 | positive regulation of NF-kappaB transcription factor activity (GO:0051092) | 4.814e-16 | 1.136e-13 | 539.95 | 19043.76 |
| 3 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 1.878e-10 | 4.924e-9 | 783.25 | 17541.62 |
| 4 | positive regulation of T cell receptor signaling pathway (GO:0050862) | 3.267e-8 | 5.139e-7 | 778.40 | 13417.28 |
| 5 | positive regulation of DNA-binding transcription factor activity (GO:0051091) | 2.059e-14 | 2.430e-12 | 331.97 | 10461.57 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | CARD domain binding (GO:0050700) | 5.717e-11 | 2.287e-9 | 1109.89 | 26176.78 |
| 2 | protein kinase B binding (GO:0043422) | 0.000006290 | 0.0001258 | 832.67 | 9972.50 |
| 3 | protein kinase C activity (GO:0004697) | 0.00002041 | 0.0002721 | 416.21 | 4494.85 |
| 4 | histone threonine kinase activity (GO:0035184) | 0.003495 | 0.01748 | 370.07 | 2093.27 |
| 5 | kinase activator activity (GO:0019209) | 0.0001038 | 0.001038 | 172.08 | 1578.44 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | aggresome (GO:0016235) | 0.0001327 | 0.002123 | 151.19 | 1349.73 |
| 2 | CD40 receptor complex (GO:0035631) | 0.005488 | 0.04390 | 222.00 | 1155.57 |
| 3 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.1449 | 41.02 | 147.91 |
| 4 | lipid droplet (GO:0005811) | 0.03785 | 0.1514 | 29.11 | 95.32 |
| 5 | mitotic spindle (GO:0072686) | 0.05842 | 0.1558 | 18.55 | 52.69 |
Hub genes predicted as biomarkers & Predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CARD10 | – |
| PRKCQ | – |
| BCL10 | – |
| MALT1 | – |
| CARD11 | – |
| PRKCB | – |
| TRAF6 | – |
| IKBKG | SULFADOXINE, ARTESUNATE, PRIMAQUINE, PYRIMETHAMINE |
| CARD14 | – |
| RRNAD1 | – |
