Oxygen desaturation on exertion (HP:0030874)
Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa.
Synonyms: O2 desaturation on exertion
Pubmed References: PMID:24121092
Cross References: UMLS:C4280731
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone synthesis | 0.0006123 | 0.01960 | 68.21 | 504.62 |
| 2 | Maturity onset diabetes of the young | 0.01293 | 0.09247 | 88.73 | 385.85 |
| 3 | Thyroid cancer | 0.01835 | 0.09247 | 61.59 | 246.23 |
| 4 | Autoimmune thyroid disease | 0.02619 | 0.09247 | 42.60 | 155.17 |
| 5 | Inflammatory bowel disease | 0.03204 | 0.09247 | 34.59 | 119.03 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | thyroid gland development (GO:0030878) | 5.033e-9 | 9.161e-7 | 1713.00 | 32730.63 |
| 2 | positive regulation of cell-cell adhesion mediated by cadherin (GO:2000049) | 0.000008085 | 0.0001471 | 713.68 | 8368.26 |
| 3 | endocrine system development (GO:0035270) | 1.812e-7 | 0.00001099 | 407.53 | 6326.45 |
| 4 | negative regulation of epithelial to mesenchymal transition (GO:0010719) | 3.266e-7 | 0.00001486 | 329.08 | 4914.57 |
| 5 | metanephric distal tubule development (GO:0072235) | 0.002498 | 0.01247 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.009991 | 555.17 | 3326.77 |
| 2 | DEAD/H-box RNA helicase binding (GO:0017151) | 0.003495 | 0.01141 | 370.07 | 2093.27 |
| 3 | aryl hydrocarbon receptor binding (GO:0017162) | 0.003994 | 0.01141 | 317.19 | 1751.86 |
| 4 | transcription regulatory region nucleic acid binding (GO:0001067) | 3.081e-8 | 0.000001232 | 95.57 | 1652.93 |
| 5 | glucocorticoid receptor binding (GO:0035259) | 0.004492 | 0.01198 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | alveolar lamellar body (GO:0097208) | 0.000003371 | 0.00004719 | 1249.13 | 15739.23 |
| 2 | multivesicular body lumen (GO:0097486) | 0.000004719 | 0.00004719 | 999.25 | 12254.80 |
| 3 | late endosome lumen (GO:0031906) | 0.000008085 | 0.00005390 | 713.68 | 8368.26 |
| 4 | lamellar body (GO:0042599) | 0.00001750 | 0.00008749 | 454.07 | 4973.59 |
| 5 | multivesicular body (GO:0005771) | 0.0002403 | 0.0009613 | 110.81 | 923.40 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NKX2-1 | – |
| PAX8 | – |
| NAPSA | – |
| KRT7 | – |
| TG | ACEBUTOLOL, AMINOGLETETHIMIDE |
| SMAD3 | — |
| NCOA1 | – |
| FOXA2 | – |
| FOXA1 | – |
| SFTPB | STREPTOZOCIN |
