Hypoxemia (HP:0012418)
An abnormally low level of blood oxygen.
Synonyms: Low blood oxygen level, Hypoxia
Comment: Note that hypoxemia is defined as a condition where arterial oxygen tension is below normal (80-100mmHg). Hypoxia is defined as the failure of oxygenation at the tissue level. Hypoxia is not measured directly by a standard laboratory value.
Cross References: MSH:D000860, SNOMEDCT_US:389087006, UMLS:C0700292
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Cardiac muscle contraction | 0.0008229 | 0.01301 | 58.54 | 415.82 |
| 2 | Hypertrophic cardiomyopathy | 0.0008802 | 0.01301 | 56.54 | 397.78 |
| 3 | Dilated cardiomyopathy | 0.001001 | 0.01301 | 52.91 | 365.49 |
| 4 | Asthma | 0.01540 | 0.08420 | 73.93 | 308.54 |
| 5 | Thyroid cancer | 0.01835 | 0.08420 | 61.59 | 246.23 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | actin-myosin filament sliding (GO:0033275) | 7.523e-7 | 0.00008577 | 244.35 | 3445.31 |
| 2 | muscle filament sliding (GO:0030049) | 7.523e-7 | 0.00008577 | 244.35 | 3445.31 |
| 3 | positive regulation of myoblast proliferation (GO:2000288) | 0.002498 | 0.01785 | 555.17 | 3326.77 |
| 4 | negative regulation of transforming growth factor beta1 production (GO:0032911) | 0.002498 | 0.01785 | 555.17 | 3326.77 |
| 5 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.01785 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | intronic transcription regulatory region sequence-specific DNA binding (GO:0001161) | 0.002498 | 0.02231 | 555.17 | 3326.77 |
| 2 | phosphatidylcholine flippase activity (GO:0140345) | 0.002498 | 0.02231 | 555.17 | 3326.77 |
| 3 | phosphatidylcholine transfer activity (GO:0120019) | 0.002498 | 0.02231 | 555.17 | 3326.77 |
| 4 | myosin heavy chain binding (GO:0032036) | 0.003495 | 0.02231 | 370.07 | 2093.27 |
| 5 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.02231 | 317.19 | 1751.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 0.002498 | 0.02197 | 555.17 | 3326.77 |
| 2 | alveolar lamellar body (GO:0097208) | 0.002997 | 0.02197 | 444.11 | 2580.41 |
| 3 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.03169 | 184.98 | 932.06 |
| 4 | lamellar body (GO:0042599) | 0.006482 | 0.03169 | 184.98 | 932.06 |
| 5 | MHC protein complex (GO:0042611) | 0.009957 | 0.04381 | 116.79 | 538.34 |
Hub genes as predicted biomarkers and FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| NKX2-1 | – |
| GATA6 | – |
| TPM3 | CORTICOTROPIN |
| MYL2 | – |
| ACTA1 | – |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| ZFPM2 | – |
| ABCA3 | – |
| BTNL2 | – |
| RHAG | – |
